macroamylase

macroamylase

 [mak″ro-am´ĭ-lās]
a complex in which normal serum amylase is bound to a variety of specific binding proteins, forming a complex too large for renal excretion. It is not correlated with any specific disease state; however, in hyperamylasemia or pancreatitis, it can result in urinary amylase levels not rising concomitantly with serum levels.

mac·ro·am·y·lase

(mak'rō-am'i-lās),
Descriptive term applied to a form of serum amylase in which the enzyme is present as a complex joined to a globulin; the molecular weight of the enzyme itself is 50,000, whereas that of the complex probably exceeds 160,000; hence, renal excretion of the complex is not appreciable.

macroamylase

A high-molecular-weight (200-kD) plasma amylase, usually of salivary type, that circulates complexed to various large plasma proteins, such as IgG, IgA, polysaccharides, glycoproteins and alpha1-antitrypsin.

mac·ro·am·y·lase

(mak'rō-am'i-lās)
A form of serum amylase in which the enzyme is joined to a globulin.
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References in periodicals archive ?
Macroamylase was the first macroenzyme described by Wilding et al.
A Rare Cause of Hyperamylasemia: Macroamylasemia / Hiperamilazeminin Nadir Bir Nedeni: Makroamilazemi
Macroamylase is a complex of amylase and serum immunoglobulins that render the particles too large to be filtered by the kidneys resulting in a high serum amylase level.
Pancreatitis
Macroamylase, macro creatine kinase, and other macroenzymes.
In search for a better marker of acute pancreatitis--third time lucky?
Circulating immunoglobulins complexed with enzymes and other proteins that are measured in the diagnostic laboratory have been recognized for many years, back at least to the recognition of macroamylase (10).
Persistent increase of cardiac troponin I in plasma without evidence of cardiac injury
University of Virginia Case Conference: macroamylase, macro creatine kinase and other macroenzymes.
Prolonged hyperlipasemia attributable to a novel type of macrolipase
The diagnosis of macrolipasemia was not pursued because <2% of the activity in the supernatant was lost (decreasing from 15 268 to 14 960 U/L) after precipitation with polyethylene glycol as described for macroamylase screening [4].
Chronic increased serum lipase in a patient with suspected pancreatic adenocarcinoma

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