Lysyl oxidase enhances the deposition of tropoelastin through the catalysis of tropoelastin molecules on the cell surface.
This can be reduced by the inhibition of
lysyl oxidase, a key enzyme involved in collagen crosslinking (29).
Martinez-Gonzalez, "
Lysyl oxidase as a potential therapeutic target," Drug News & Perspectives, vol.
Kagan, "
Lysyl oxidase: an oxidative enzyme and effector of cell function," Cellular and Molecular Life Sciences, vol.
(2) in ER [right arrow] preprocollagen, (3) ER Lumen [right arrow] signal peptides cleaved; proline and lysine hydroxylation, 2 pro-alpha1 and 1 pro-alpha2 chains [right arrow] Type I procollagen, triple helix formed [right arrow] (4) in Golgi packaged and secreted [right arrow] (5) outside cell propeptides cleaved [right arrow] tropocollagen fibrils formed, (6)
lysyl oxidase creates intramolecular and intermolecular cross-links.
BAPN leads to lathyrism by inhibiting
lysyl oxidase, which is an important enzyme in the synthesis of collagen and elastin.
Lysyl oxidase is required for crosslink of tropoelastin to from elastin.
Congenital cutis laxa and
lysyl oxidase deficiency.
Hypoxia-induced
lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche.
Copper is a cofactor for
lysyl oxidase, an enzyme involved in the maturation or cross-linking of collagen to form stable fibrils upon which calcium is deposited to form bone.
Through a molecular approach called differential display analysis, Hendrix's team identified the gene
lysyl oxidase and a zinc finger transcription factor in highly aggressive breast cancer cells that spread.
A collagen-specific enzyme,
lysyl oxidase, crosslinks these trimers into fibrils or meshworks.
