enhances the deposition of tropoelastin through the catalysis of tropoelastin molecules on the cell surface.
This can be reduced by the inhibition of lysyl oxidase
, a key enzyme involved in collagen crosslinking (29).
Martinez-Gonzalez, "Lysyl oxidase
as a potential therapeutic target," Drug News & Perspectives, vol.
Kagan, "Lysyl oxidase
: an oxidative enzyme and effector of cell function," Cellular and Molecular Life Sciences, vol.
(2) in ER [right arrow] preprocollagen, (3) ER Lumen [right arrow] signal peptides cleaved; proline and lysine hydroxylation, 2 pro-alpha1 and 1 pro-alpha2 chains [right arrow] Type I procollagen, triple helix formed [right arrow] (4) in Golgi packaged and secreted [right arrow] (5) outside cell propeptides cleaved [right arrow] tropocollagen fibrils formed, (6) lysyl oxidase
creates intramolecular and intermolecular cross-links.
BAPN leads to lathyrism by inhibiting lysyl oxidase
, which is an important enzyme in the synthesis of collagen and elastin.
is required for crosslink of tropoelastin to from elastin.
Congenital cutis laxa and lysyl oxidase
Hypoxia-induced lysyl oxidase
is a critical mediator of bone marrow cell recruitment to form the premetastatic niche.
Copper is a cofactor for lysyl oxidase
, an enzyme involved in the maturation or cross-linking of collagen to form stable fibrils upon which calcium is deposited to form bone.
Through a molecular approach called differential display analysis, Hendrix's team identified the gene lysyl oxidase
and a zinc finger transcription factor in highly aggressive breast cancer cells that spread.
A collagen-specific enzyme, lysyl oxidase
, crosslinks these trimers into fibrils or meshworks.