lysyl oxidase


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ly·syl ox·i·dase

[MIM*153455]
an enzyme, which requires Cu2+ and O2, that oxidizes certain lysyl residues in collagen to allysyl residues and hydroxylysyl residues to hydroxyallysyl residues; this is a required step for the cross-linking (via aldol condensations and through Amadori rearrangements) of collagen strands; a lower activity of this enzyme is associated with occipital horn syndrome.

Lysyl oxidase

An enzyme required for the crosslinking of elastin and collagen molecules to form properly functioning connective tissue; present in relatively low levels in at least some forms of cutis laxa.
Mentioned in: Cutis Laxa

lysyl oxidase

a copper-containing enzyme responsible for the maintenance of collagen and elastin in tissues; its absence leads to aneurysm formation in and rupture of large blood vessels.
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References in periodicals archive ?
Increased lysyl oxidase activity in blood vessels of hypertensive rats and effect of betaaminopropionitrile on arteriosclerosis.
Lysyl oxidases in mammalian development and certain pathological conditions.
The relationship of pulmonary artery copper concentrations and genes involved in copper homeostasis in cattle, swine, and goats
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche.
Alternative splicing variant of kallikrein-related peptidase 8 as an independent predictor of unfavorable prognosis in lung cancer
Second are similarities of post-translational pathways, such as lysyl oxidase crosslinking.
The developmental role of the extracellular matrix suggests a monophyletic origin of the kingdom Animalia
But the defective gene does not code for lysyl oxidase.
Congenital cutis laxa with pneumonia: a rare case in pediatric practice
Copper, lysyl oxidase, and extracellular matrix protein cross-linking.
Trace mineral nutrition in poultry and swine
While studying breast cancer in mice, Janine's team have found that in the absence of the LOX enzyme, full name lysyl oxidase, new environments in the body would be too hostile for the cancer to grow.
Cancer cure may be available within five years, say researchers
The lysyl oxidases lysyl oxidase (LOX) and (LOXL) are responsible for elastin cross-linking.
What's new in cosmetic R&D? Most research and new product development is focused on natural materials and actives that combat the signs of aging
Lysyl oxidase, which catalyzes the posttranslational modification essential to the pathogenesis of connective tissue matrices, is irreversibly inactivated by homocysteine thiolactone (10).
Protein-bound homocystamide measured in human plasma by HPLC

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