lysyl

ly·syl (K),

(lī'sil),
The univalent radical of lysine.
References in periodicals archive ?
(13,14) IgF-1 is a potent promoter of type 1 and 3 collagen biosynthesis, as well as of the ECM-essential enzymes lysyl oxidase and lysyl hydroxylase.
Proteins associated with hypoxia in solid tumors include VEGF, BNIP3, lysyl oxidase, plasminogen activator inhibitor-1, lactate dehydrogenase isoenzyme-5, and galectin-1.
In particular, lysyl hydroxylase, a cartilaginous enzyme required for the formation of hydroxylysine residues and crosslinking, is inhibited by the HGA oxidation process (5).
Several genes have been recognized as most responsible for development of PEX syndrome, in particular lysyl oxidase-like 1 (LOXL1) gene polymorphism on chromosome 15q24.1 in the populations investigated, with a contribution of additional genes with relatively small effects (clustrein, contactin associated protein-like 2 (CNTNAP2), apolipoprotein E, glutathione S-transferase, adenosine, and tumor necrosis factor-alpha (TNF-[alpha])).
Interstitial lung fibrosis may also occur in diabetes, increase in activity of lysyl oxidase.
Pharmaceutical company Pharmaxis announced positive results from the Phase 1 clinical trial for the second of its Lysyl Oxidase Like 2 (LOXL2) inhibitor compounds being developed to treat fibrotic diseases such as Non?Alcoholic Steatohepatitis (NASH) and Idiopathic Pulmonary Fibrosis (IPF).
Association of Lysyl Oxidase-Like 1 Gene Polymorphism in Turkish Patients With Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma.
Decreased expression of lysyl oxidase was seen in aortic tissues from challenged mice that received ciprofloxacin versus challenged control mice.
This allows the segregation of different cell types during which we have recently published (23, 24) Accordingly the aim of this study was to improve on the development of tissue engineered buccal mucosa for future clinical use by comparing a synthetic trilayer (PLA-PHBV-PLA) biodegradable alternative to human dermis and further to explore the use of beta-aminopropionitrile ([beta]-APN) as a lysyl oxidase inhibitor to reduce contraction in these grafts.