(13,14) IgF-1 is a potent promoter of type 1 and 3 collagen biosynthesis, as well as of the ECM-essential enzymes lysyl
oxidase and lysyl
oxidase (LOX) is a 32-kDa extracellular copper ion-dependent amino acyl oxidase.
Proteins associated with hypoxia in solid tumors include VEGF, BNIP3, lysyl
oxidase, plasminogen activator inhibitor-1, lactate dehydrogenase isoenzyme-5, and galectin-1.
In particular, lysyl
hydroxylase, a cartilaginous enzyme required for the formation of hydroxylysine residues and crosslinking, is inhibited by the HGA oxidation process (5).
Several genes have been recognized as most responsible for development of PEX syndrome, in particular lysyl
oxidase-like 1 (LOXL1) gene polymorphism on chromosome 15q24.1 in the populations investigated, with a contribution of additional genes with relatively small effects (clustrein, contactin associated protein-like 2 (CNTNAP2), apolipoprotein E, glutathione S-transferase, adenosine, and tumor necrosis factor-alpha (TNF-[alpha])).
Suppression of lysyl
oxidase gene expression by methylation in pelvic organ prolapse.
Interstitial lung fibrosis may also occur in diabetes, increase in activity of lysyl
Insilico study of anti-carcinogenic lysyl
oxidase-like 2 inhibitors.
Pharmaceutical company Pharmaxis announced positive results from the Phase 1 clinical trial for the second of its Lysyl
Oxidase Like 2 (LOXL2) inhibitor compounds being developed to treat fibrotic diseases such as Non?Alcoholic Steatohepatitis (NASH) and Idiopathic Pulmonary Fibrosis (IPF).
Association of Lysyl
Oxidase-Like 1 Gene Polymorphism in Turkish Patients With Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma.
Decreased expression of lysyl
oxidase was seen in aortic tissues from challenged mice that received ciprofloxacin versus challenged control mice.
This allows the segregation of different cell types during which we have recently published (23, 24) Accordingly the aim of this study was to improve on the development of tissue engineered buccal mucosa for future clinical use by comparing a synthetic trilayer (PLA-PHBV-PLA) biodegradable alternative to human dermis and further to explore the use of beta-aminopropionitrile ([beta]-APN) as a lysyl
oxidase inhibitor to reduce contraction in these grafts.