(redirected from lysosomal phospholipidosis)


Relating to lysosomes.


(lī′sŏ-sōm″) [ lyso- + -some]
An organelle that is part of the intracellular digestive system. The lysosome contains within its limiting membrane hydrolytic enzymes that break down proteins and carbohydrates. Lysosomal enzymes contribute to the digestion of pathogens phagocytized by a cell and also to the tissue damage that accompanies inflammation.
lysosomal (lī″sŏ-sōm′ăl), adjective


pertaining to or emanating from lysosomes.

lysosomal enzymes
enzymes located in the lysosomes.
lysosomal phospholipidosis
overloading of lysosomes with phospholipids as caused by the inhibition of phospholipidases by aminoglycosides.
lysosomal storage diseases
diseases in which there is a congenital or acquired deficiency of an enzyme so that one or more specific metabolic processes are not completed. As a result there is an accumulation of metabolic products in the cellular lysosomes. The histological lesion indicates the error in function but not the cause. Most of these diseases are inherited but swainsonine poisoning is caused by plant (Swainsona, Astragalus, Trachyandra spp.) poisoning. See also ceroid lipofuscinosis, glycogenosis, glycoproteinosis, lipid storage disease, mucopolysaccharidosis.
References in periodicals archive ?
2003) Silymarin and vitamin E reduce amiodarone-induced lysosomal phospholipidosis in rats.

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