"Long-lived proteins become more problematic as we age and could account for the lysosomal
storage seen in Alzheimer's, an age-related disease," Julian said.
A new method for the measurement of lysosomal
acid lipase in dried blood spots using the inhibitor Lalistat 2.
IntraBio's clinical programs leverage the expertise of its scientific founders from the University of Oxford and University of Munich, preeminent experts in lysosomal
function and intracellular calcium signaling.
(1.) Htmes RW, Barlow SE, Bove K, Qutntantlh NM, Sheridan R, Kohh R Lysosomal
Acid Lipase Deficiency Unmasked in Two Children with Nonalcoholic Fatty Liver Disease Pediatrics 2016, 138.
The AMFA compound is designed to target a specific membrane lectin, the mannose 6-phosphate (M6P) receptor, a major intracellular lysosomal
Epidemiology and diagnosis of lysosomal
storage disorders; challenges of screening.
This is the first study that evaluated the relationship between lysosomal
exoglycosidase profile and secretory function of the parotid and submandibular glands of rats with STZ-induced diabetes.
Clinically, LAL deficiency, like other lysosomal
storage disorders, can present across the age spectrum.
Chennai (Tamil Nadu) [India], Oct 17 ( ANI ): Emphasising on the importance of timely treatment for Lysosomal
Storage Disorders (LSDs), medical experts urged for concrete steps to be taken in this direction.
The literature search was done using Pubmed and Clinical trials databases using key words: "Lysosomal
storage disorders", "natural course", "ethics", "cascade screening", "Thalassemia" and "cascade screening".
Newborn screening for lysosomal
storage diseases (LSDs) has gained interest worldwide with the increasing availability of effective treatment options and accessible screening methods.
Enzyme stability in DBS is an important issue that has been addressed previously for 5 lysosomal