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Related to lysosomal: Lysosomal enzymes


Relating to lysosomes.


(lī′sŏ-sōm″) [ lyso- + -some]
An organelle that is part of the intracellular digestive system. The lysosome contains within its limiting membrane hydrolytic enzymes that break down proteins and carbohydrates. Lysosomal enzymes contribute to the digestion of pathogens phagocytized by a cell and also to the tissue damage that accompanies inflammation.
lysosomal (lī″sŏ-sōm′ăl), adjective


pertaining to or emanating from lysosomes.

lysosomal enzymes
enzymes located in the lysosomes.
lysosomal phospholipidosis
overloading of lysosomes with phospholipids as caused by the inhibition of phospholipidases by aminoglycosides.
lysosomal storage diseases
diseases in which there is a congenital or acquired deficiency of an enzyme so that one or more specific metabolic processes are not completed. As a result there is an accumulation of metabolic products in the cellular lysosomes. The histological lesion indicates the error in function but not the cause. Most of these diseases are inherited but swainsonine poisoning is caused by plant (Swainsona, Astragalus, Trachyandra spp.) poisoning. See also ceroid lipofuscinosis, glycogenosis, glycoproteinosis, lipid storage disease, mucopolysaccharidosis.
References in periodicals archive ?
Cost of enzyme replacement therapy for lysosomal storage disorders in the back drop of Pakistan economic and health care priorities: Over the last quarter of the century, the evolution of treatment of LSDs has been enormous.
After 15 weeks, hepatocytes were isolated from three mice of each group to assay lysosomal status and intralysosomal iron content.
Lysosomal storage disorders affect mostly children and due to lack of awareness the diagnosis is often made late hence almost 30 per cent of those affected children die at a young age.
c) LSD biomarker quantification; and (d) sequencing of the gene encoding the lysosomal protein.
Globoid cell leukodystrophy (GLD) or Krabbe disease (KD) is an inherited neurodegenerative lysosomal enzyme disorder affecting the central and peripheral nervous systems.
What regulates the limited release of CatD from the lysosomal membrane, and the signaling mechanism(s) remains to be fully elucidated.
This report provides information on the therapeutic development for Lysosomal Storage Disorder, complete with latest updates, and special features on late-stage and discontinued projects.
Cord blood has been proposed as an alternative stem cell source for children with HS since it has been suggested that cord blood may increase their levels of lysosomal a-L-iduronidase, which consequently may allow them to live longer with fewer complications," said lead study author jaap Jan Boelens, M.
Summary: TEHRAN (FNA)- Researchers have overcome a major challenge to treating brain diseases by engineering an experimental molecular therapy that crosses the blood-brain barrier to reverse neurological lysosomal storage disease in mice.
Sialidosis is an autosomal recessive lysosomal storage disease characterized by accumulation of sialyloligosaccharides in the blood, tissues and urine occuring as a result of mutaton of the gene coding lysosomal sialydase (neuraminidase) enzyme localized on the short arm of th 6th chromosome (1,2).
The company's lead programme is SBC-102, which is a recombinant form of the human LAL enzyme being developed as an enzyme replacement therapy for Lysosomal Acid Lipase Deficiency, a lysosomal storage disorder.
Hurler's syndrome is a lysosomal storage disorder that affects approximately one of every 100,000 children.

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