Modulation of the cold-activated channel TRPM8 by lysophospholipids
and polyunsaturated fatty acids.
or their metabolites, such as lysophosphatidic acid (LPA) and platelet-activating factor (PAF), are categorized into another class of [PLA.
2]) could catalyze the hydrolysis of membrane phospholipids producing lysophospholipids
which leads to the loss of osmolytes and cell water, but in our previous studies HSP90 could protect phospholipid from [PLA.
Shinitzky, Enhancement and Inhibition of Snake Venom Phosphodiesterase Activity by Lysophospholipids
, FEBS Lett.
The protein phospholipase A2, PLA2G2A, belongs to the PLA2 superfamily that catalyzes the hydrolysis of glycerophospholipids to yield fatty acids and lysophospholipids
The secreted lipase autotaxin hydrolyzes lysophospholipids
to LPA, which subsequently binds to its receptors LPAR1-LPAR6.
Recognition of lysophospholipids
by human natural killer T lymphocytes," PLoS Biology, vol.
The major factors that can differentially modify PON and ARE activity are lysophospholipids
In recent years, more and more data have appeared about regulatory effects of lysophospholipids
(LPL) which work as mediators that cause a variety of cellular responses.
in particular play an important role in regulating cell fluidity and permeability.
After binding PLA2 enzyme caused hydrolysis of intact phospholipids and released free fatty acids and lysophospholipids
Current studies have been evaluating the effectiveness of lysophospholipids
, growth factor, soluble urinary type plasminogen activator, matrix metalloproteinases, hypermethylated gene products, extracellular matrix proteins, HE4-protein overexpression and ovarian screening using saliva testing as mechanisms for the detection of ovarian cancer.