In addition, neutrophils degrade inflammatory cytokines by aggregated NETs, secrete soluble factors, including azurocidin, cathepsin G, lipoxins, and lysophosphatidylserine
, and are able to reprogramme macrophages to the regulatory M2 phenotype [6, 12-15].
(2013) ABHD12 controls brain lysophosphatidylserine
pathways that are deregulated in a murine model of the neurodegenerative disease PHARC.
As a result of these discoveries and subsequent patent filing, the two companies have formally announced their patent "Methods using phosphatidylserine, lysophosphatidylserine
, and/or salts thereof to increase testosterone levels" (U.S.
(2006) revealed the novel functions of L-Ser and its analogs and derivatives (D-Ser, glycine, acetylserine, phosphoserine, L-Cys and lysophosphatidylserine
) under an acute stressful condition in neonatal chicks.
activates toll-like receptor 2 and affects immune polarization," Journal of Biological Chemistry, vol.
In addition to inducing macrophage reprogramming, enhanced levels of cAMP induced by binding to lysophosphatidylserine (lysoPS) expressed on apoptotic neutrophils are also involved in efferocytosis [50, 51].
Fernandez-Boyanapalli et al., "NADPH oxidase-dependent generation of lysophosphatidylserine enhances clearance of activated and dying neutrophils via G2A," The Journal of Biological Chemistry, vol.