lysophosphatidylcholine


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ly·so·phos·pha·ti·dyl·cho·line

(lī'sō-fos'fă-tī'dil-kō'lēn),
A phosphatidylcholine in which a fatty acyl moiety has been removed from the C2 position of the glycerol group.
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lysophosphatidic acid and lysophosphatidylcholine (LPC), [1] or the group of lysosphingolipids, e.
High-throughput quantification of lysophosphatidylcholine by electrospray ionization tandem mass spectrometry
Although NMR identified one altered metabolite (phosphorylcholine) involved into glycerophospholipid metabolism, LC-MS identified a series of lysophosphatidylcholines including LPCs (6, 8-17, 19 and 20).
UPLC-Q/TOF MS standardized Chinese formula Xin-Ke-Shu for the treatment of atherosclerosis in a rabbit model
Moreover, a proatherogenic role of PAF-AH has been hypothesized, based on the fact that, during hydrolysis of oxidized phospholipids, PAF-AH also produces lysophosphatidylcholine and oxidized fatty acids, inflammatory mediators that could promote atherogenesis (6).
Platelet-activating factor acetylhydrolase is not associated with carotid intima-media thickness in hypercholesterolemic Sicilian individuals
Lysophosphatidylcholine hydrolases of human erythrocytes, lymphocytes and brain: sensitive targets of conserved specificity for organophosphorus delayed neurotoxicants.
The greening of pesticide-environment interactions: some personal observations
Enhanced expression of Lp-PLA2 and lysophosphatidylcholine in symptomatic carotid atherosclerotic plaques.
Detect your risk of sudden heart attack and stroke
Lysophosphatidylcholine and secretory phospholipase A2 in vascular disease: mediators of endothelial dysfunction and atherosclerosis.
Relationship among plasma secretory phospholipase [A.sub.2], oxidized low density lipoprotein & paraoxonase activities in hypertensive subjects treated with angiotensin converting enzyme inhibitors
2] is highly upregulated in atherosclerotic plaque; and through hydrolysis of oxidized LDL, this enzyme generates two pro-inflammatory mediators, lysophosphatidylcholine and non-esterified oxidized fatty acid.
Biomarkers for cardiovascular risk assessment
The chemoattractant activity of LDL resides in its lipid moiety, and is attributable to lysophosphatidylcholine generation during the conversion of LDL into its oxidized form.
Cardiovascular disease and risk factors
The LPA1 receptor is part of the Phosphatidic Acid/ Lysophosphatidylcholine pathway and has recently been implicated for having a role in lung, kidney and skin fibrosis.
Anti-Fibrotic Data from Amira Pharmaceuticals' LPA1 Receptor Antagonist Program Published in the British Journal of Pharmacology
Mapstone and his associates identified a set of 10 metabolites that comprised phosphatidylcholines, lysophosphatidylcholine, and acylcarnitines, which were each found at much lower levels in the plasma of the converter group before conversion than in the plasma of the cognitively normal group.
Plasma biomarker panel predicts amnestic MCI or AD
In addition, a flavonoid glycoside, and lysophosphatidylcholine derivatives were detected by ESI-MS analysis of the bufadienolide fraction.
Inhibition of porcine detrusor contractility by the flavonoid fraction of Bryophyllum pinnatum--a potential phytotherapeutic drug for the treatment of the overactive bladder syndrome
A total of 116 lipids were identified and quantified by UPLC-TOF ESI-positive mode that were distributed as follows: five classes of glycerophospholipids [phosphocholine (PC) with 20 lipids, lysophosphatidylcholine (LPC) with 6 lipids, phosphatidylethanolamine (PE) with 9 lipids, phosphatidylserine (PS) with 7 lipids, and phosphatidylinositol (PI) with 3 lipids]; diacylglycerols (DG) with 20 lipids; triacylglycerols (TG) with 39 lipids; cholesterylesters (CE) with 4 lipids; and sphingolipids (SM) with 8 lipids.
Obesogens beyond vertebrates: lipid perturbation by tributyltin in the crustacean daphnia magna

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