lysophosphatidylcholine


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ly·so·phos·pha·ti·dyl·cho·line

(lī'sō-fos'fă-tī'dil-kō'lēn),
A phosphatidylcholine in which a fatty acyl moiety has been removed from the C2 position of the glycerol group.
Farlex Partner Medical Dictionary © Farlex 2012
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LPA is produced by fatty acid deacylation of phosphatidic acid (PA) by [PLA.sub.2] (or [PLA.sub.1]), or by removal of the polar head group of lysophosphatidylcholine (LPC), which is produced from PC by [PLA.sub.2] (or [PLA.sub.1]), by a lysophospholipase D termed autotaxin (ATX).
Lipoquality control by phospholipase [A.sub.2] enzymes
Shimada, "Lysophosphatidylcholine induces apoptosis in human endothelial cells through a p38-mitogen-activated protein kinase-dependent mechanism," Atherosclerosis, vol.
QGQS Granule in SHR Serum Metabonomics Study Based on Tools of UPLC-Q-TOF and Renin-Angiotensin-Aldosterone System Form Protein Profilin-1
Isomeric sn-1-octadecenyl and sn-2- octadecenyl analogues of lysophosphatidylcholine as substrates for acylation and desaturation by plant microsomal membranes.
Differential Gene Regulation of Lipid Synthesis in the Developing Seeds of Two Biodiesel Tree Species, Jatropha and Vernicia
Along with an increase in maintenance of total phospholipids (TP) (P < 0.01), fractions of lysophosphatidylcholine (LPC), phosphatidylserine (PS), phosphatidylethanolamine (PEA) (P < 0.05) raise and the maintenance of fractions sphingomyelin (SPM) (P < 0.01), phosphatidylcholine (PC) (P < 0.01) decreases that lead to an increase in a value of the coefficient saying of a relation between easily oxidizable (PS, PEA) to difficult oxidizable (SPM, PC).
Structure and function of erythrocyte membranes in moderate degree iron-deficiency anemia in early-age children in mountain conditions
PNPLA6 encodes for neuropathy target esterase (NTE), a lysophospholipase that maintains intracellular phospholipid homeostasis by converting lysophosphatidylcholine to glycerophosphocholine (42).
Idiopathic Hypogonadotropic Hypogonadism Caused by Inactivating Mutations in SRA1
Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells.
Targeted metabolomic profiling of cardioprotective effect of Ginkgo biloba L. extract on myocardial ischemia in rats
Self-ligands for CD1a can be either permissive, such as lysophosphatidylcholine that allows activation of autoreactive T cells as it allows the contact of the CD1a with the TCR, or nonpermissive, such as sphingomyelin that disrupts the TCR-CD1a contact zone and in this way does not allow activation of CD1a-restricted T cells [48].
CDl-Restricted T Cells at the Crossroad of Innate and Adaptive Immunity
Some have suggested that lysophosphatidylcholine (LPC) may be a likely candidate.
Epithelial Sodium and Chloride Channels and Asthma
A total of 116 lipids were identified and quantified by UPLC-TOF ESI-positive mode that were distributed as follows: five classes of glycerophospholipids [phosphocholine (PC) with 20 lipids, lysophosphatidylcholine (LPC) with 6 lipids, phosphatidylethanolamine (PE) with 9 lipids, phosphatidylserine (PS) with 7 lipids, and phosphatidylinositol (PI) with 3 lipids]; diacylglycerols (DG) with 20 lipids; triacylglycerols (TG) with 39 lipids; cholesterylesters (CE) with 4 lipids; and sphingolipids (SM) with 8 lipids.
Obesogens beyond vertebrates: lipid perturbation by tributyltin in the crustacean daphnia magna
A special place is occupied by lysophosphatidic acid, lysophosphatidylcholine (LPC), and a number of lysosphingolipids [10-12].
Influence of potassium hyaluronate on the content of lysophospholipids and free fatty acids in damaged somatic nerves of rat
Mapstone and his associates identified a set of 10 metabolites that comprised phosphatidylcholines, lysophosphatidylcholine, and acylcarnitines, which were each found at much lower levels in the plasma of the converter group before conversion than in the plasma of the cognitively normal group.
Plasma biomarker panel predicts amnestic MCI or AD
Particularly in ox-LDL, in which the phospholipids have undergone extensive oxidative modification, the action of [Lp-PLA.sub.2] results in the release of oxidized nonesterified fatty acids (FA) and lysophosphatidylcholine (lyso-PtdCho) [27].
The impact of rapid weight loss on oxidative stress markers and the expression of the metabolic syndrome in obese individuals

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