lysophosphatidylcholine


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ly·so·phos·pha·ti·dyl·cho·line

(lī'sō-fos'fă-tī'dil-kō'lēn),
A phosphatidylcholine in which a fatty acyl moiety has been removed from the C2 position of the glycerol group.
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lysophosphatidic acid and lysophosphatidylcholine (LPC), [1] or the group of lysosphingolipids, e.
Although NMR identified one altered metabolite (phosphorylcholine) involved into glycerophospholipid metabolism, LC-MS identified a series of lysophosphatidylcholines including LPCs (6, 8-17, 19 and 20).
Moreover, a proatherogenic role of PAF-AH has been hypothesized, based on the fact that, during hydrolysis of oxidized phospholipids, PAF-AH also produces lysophosphatidylcholine and oxidized fatty acids, inflammatory mediators that could promote atherogenesis (6).
Lysophosphatidylcholine hydrolases of human erythrocytes, lymphocytes and brain: sensitive targets of conserved specificity for organophosphorus delayed neurotoxicants.
Enhanced expression of Lp-PLA2 and lysophosphatidylcholine in symptomatic carotid atherosclerotic plaques.
Lysophosphatidylcholine and secretory phospholipase A2 in vascular disease: mediators of endothelial dysfunction and atherosclerosis.
2] is highly upregulated in atherosclerotic plaque; and through hydrolysis of oxidized LDL, this enzyme generates two pro-inflammatory mediators, lysophosphatidylcholine and non-esterified oxidized fatty acid.
The chemoattractant activity of LDL resides in its lipid moiety, and is attributable to lysophosphatidylcholine generation during the conversion of LDL into its oxidized form.
The LPA1 receptor is part of the Phosphatidic Acid/ Lysophosphatidylcholine pathway and has recently been implicated for having a role in lung, kidney and skin fibrosis.
Mapstone and his associates identified a set of 10 metabolites that comprised phosphatidylcholines, lysophosphatidylcholine, and acylcarnitines, which were each found at much lower levels in the plasma of the converter group before conversion than in the plasma of the cognitively normal group.
In addition, a flavonoid glycoside, and lysophosphatidylcholine derivatives were detected by ESI-MS analysis of the bufadienolide fraction.
A total of 116 lipids were identified and quantified by UPLC-TOF ESI-positive mode that were distributed as follows: five classes of glycerophospholipids [phosphocholine (PC) with 20 lipids, lysophosphatidylcholine (LPC) with 6 lipids, phosphatidylethanolamine (PE) with 9 lipids, phosphatidylserine (PS) with 7 lipids, and phosphatidylinositol (PI) with 3 lipids]; diacylglycerols (DG) with 20 lipids; triacylglycerols (TG) with 39 lipids; cholesterylesters (CE) with 4 lipids; and sphingolipids (SM) with 8 lipids.

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