LPAR6

(redirected from lysophosphatidic acid receptor 6)

LPAR6

A gene on chromosome 13q14 that encodes a G protein-coupled receptor preferentially activated by adenosine and uridine nucleotides.
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References in periodicals archive ?
Mutations in the LPAR6 (MIM 609239) and LIPH (MIM 607365) genes have been reported to cause autosomal recessive WH/hypotrichosis phenotype in various families.6,7 The LPAR6 and LIPH genes have been shown to have a common signalling pathway and are involved in hair growth in humans.8 The LPAR6 gene encodes lysophosphatidic acid receptor 6 (LPAR6), whereas, the LIPH codes for lipase H (or a membrane-associated phosphatidic acid-selective phospholipase A1a [mPA-PLA1a]) that produce 2-acyl lysophosphatidic acid (LPA).8,9 LPA plays an important role in various biological functions and is a ligand of LPAR6.8,9 The protein products of LPAR6 and LIPH gene are abundantly expressed in the inner root sheath (IRS) of the hair follicle.
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