KDM1B(redirected from lysine-specific histone demethylase 1B)
KDM1BA gene on chromosome 6p22.3 that encodes a demethylase which acts on histone H3, a specific tag for epigenetic transcriptional activation. KDM1B is required for de novo DNA methylation of a subset of imprinted genes during oogenesis; it acts by oxidising the substrate by flavin-containing amine oxidase domain (FAD)-containing protein 1 to generate the corresponding imine, which is subsequently hydrolysed.
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