KDM2B

(redirected from lysine-specific demethylase 2B)

KDM2B

A gene on chromosome 12q24.31 that encodes lysine-specific demethylase 2B, which demethylates histone H3. KDM2B preferentially binds the transcribed region of ribosomal RNA, represses ribosomal RNA gene transcription and inhibits cell growth and proliferation. It may also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F)-box protein-type E3 ubiquitin ligase complex.
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References in periodicals archive ?
Abbreviations BSP: Bone sialoprotein EZH2: Enhancer of zeste homolog 2 FBS: Fetal bovine serum FITC: Fluorescein isothiocyanate KDM2A: Lysine-specific demethylase 2A KDM2B: Lysine-specific demethylase 2B OCN: Osteocalcin PI: Propidium iodide Runx2: Runt-related transcription factor 2.