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the creation of a stable preparation of a biologic substance by rapid freezing and dehydration of the frozen product under high vacuum. See also freeze-drying.
1. The process of isolating a solid substance from solution by freezing the solution and evaporating the ice under vacuum.
2. The process of imparting lyophilic properties to a substance.
lyophilizationFreeze drying A method for preserving foods or biologicals, where a substance–eg, coagulation factor VIII, is 'snap-frozen' in liquid nitrogen–-70ºC and placed in a high vacuum to remove the water vapor as it sublimes; once the water is removed, the substance is brought to room temperature and stored. Cf Quick-freeze technique.
The process of isolating a solid substance from solution by freezing the solution and evaporating the ice under vacuum.