lyophilization


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lyophilization

 [li-of″ĭ-lĭ-za´shun]
the creation of a stable preparation of a biologic substance by rapid freezing and dehydration of the frozen product under high vacuum. See also freeze-drying.

ly·oph·i·li·za·tion

(lī-of'i-li-zā'shŭn),
1. The process of isolating a solid substance from solution by freezing the solution and evaporating the ice under vacuum.
2. The process of imparting lyophilic properties to a substance.
Synonym(s): freeze-drying

lyophilization

Freeze drying A method for preserving foods or biologicals, where a substance–eg, coagulation factor VIII, is 'snap-frozen' in liquid nitrogen–-70ºC and placed in a high vacuum to remove the water vapor as it sublimes; once the water is removed, the substance is brought to room temperature and stored. Cf Quick-freeze technique.

ly·oph·i·li·za·tion

(lī-of'i-lī-zā'shŭn)
The process of isolating a solid substance from solution by freezing the solution and evaporating the ice under vacuum.
Synonym(s): freeze-drying.

lyophilization

see FREEZE-DRYING.
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References in periodicals archive ?
What is your role within the field of Lyophilization and what perspective do you bring to the 2019 conference?
LSNE has been providing contract lyophilization services to the pharmaceutical, biotechnology and medical device industries since 1997, specialising in a range of services including lyophilization cycle development, cGMP fill finish, and lyophilization.
Lyophilization Services of New England, Inc ("LSNE") is a privately held company with three GMP facilities located in New Hampshire.
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Since World War II (WWII) lyophilization has been used to stabilize living cells and fungal isolates.
For good lyophilization, the vacuum should be as low as possible, and ideally below 0.1 mbar.
The results indicated a better amount and quality for the genomic DNA extracted using the modified method with the previous tissue lyophilization and the addition of PVP before the maceration step.
The non-profit centre, also known as Regen Med, is finalizing a new business plan and contract that will bring the lyophilization method and some advanced tissue cutting techniques to Thunder Bay.
Lyophilization, also referred to as freeze drying, is an important sample processing and preparation tool for many laboratories.
This compilation of new research on one of the most important and frustrating aspects of research in this field has been completely updated and features notes for each protocol, methods for conservation and sustainable use of resources, methods for lyophilization of proteins, and new and new techniques for preserving biological materials.