lymphotoxin


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lymphotoxin

 [lim´fo-tok″sin]
a lymphokine containing 171 amino acids, one of the tumor necrosis factors, produced by activated T lymphocytes. It inhibits the growth of tumors by causing lysis or stasis of sensitive cells, and also blocks transformation of cells. Called also tumor necrosis factor β.

lym·pho·tox·in

(lim'fō-tok'sin),
A lymphokine from T lymphocytes that lyses or damages many cell types.

lymphotoxin

/lym·pho·tox·in/ (lim´fo-tok″sin) tumor necrosis factor ; a lymphokine produced by activated T lymphocytes that it inhibits growth of tumors and blocks transformation of cells.

lymphotoxin

(lĭm′fə-tŏk′sĭn)
n.
A lymphokine that is toxic to certain susceptible target cells.

lym·pho·tox·in

(lim'fō-tok'sin)
A lymphokine that lyses or damages many cell types.

lymphotoxin

a lymphokine released by antigen-stimulated lymphocytes, particularly cytotoxic T lymphocytes, and involved in target-cell lysis, as in virus-infected target cells. The killing requires cell-to-cell contact and is restricted by Class I major histocompatibility antigens. Called also tumor necrosis factor-β (TNF-β).
References in periodicals archive ?
Tumor necrosis factor a and lymphotoxin are not required for induction of acute experimental autoimmune encephalomyelitis.
Another group of cytokines from the lymphotoxin family have been implicated in inflammatory diseases.
Mice lacking lymphotoxin, they found, do not gain extra weight, even after prolonged consumption of a high-fat diet.
Essential role of nuclear factor (NF)-[kappa]B-inducing kinase and inhibitor of [kappa]B (I[kappa]B) kinase[alpha] in NF-[kappa]B activation through lymphotoxin p receptor, but not through tumor necrosis factor receptor I.
Lymphotoxin alpha and TNF have essential dependence but independent roles in the evolution of the granulomatous response in experimental leprosy.
He was homozygous for 4 gene polymorphisms associated with higher susceptibility or severity of severe sepsis or both and ARDS: CD14, lymphotoxin alpha, TNF-alpha, IRAK-1, and IL-6 (6-9).
Structural deficiencies in granuloma formation in TNF gene targeted mice underlie the heightened susceptibility to aerosol Mvcobacterium tuberculosis infection, which is not compensated for by lymphotoxin.
Isolated lymphoid follicle formation is inducible and dependent upon lymphotoxin-sufficient B lymphocytes, lymphotoxin beta receptor, and TNF receptor I function.
The interaction of the polymorphisms in transporter of antigen peptides (TAP) and lymphotoxin alpha (LT-alpha) genes and atopic diseases in the Czech population.
Livingston JC, Park V, Barton JR,Lack of association of severe preeclampsia with maternal and fetal mutant alleles for tumor necrosis factor alpha and lymphotoxin alpha genes and plasma tumor necrosis factor alpha levels.
Enbrel[R] binds with tumor necrosis factor alpha (TNF alpha - a cytokine*), inhibiting its activity, and with lymphotoxin alpha (another cytokine), and reduces RA inflammation.
27) Polymorphisms in a number of genes such as uteroglobin (which has anti-inflammatory/immunomodulatory properties), TNF-[beta]*2, human leukocyte antigen (HLA) B54 (HLAB54), CFTR, lymphotoxin a (LTA), transforming growth factor [beta] (TGFB1), IL-1 receptor agonist (TL1RN), IL-22, [alpha]-1 antitrypsin, mesenchymal-epithelial transition (MET), and [beta]2 adrenoceptor (ADRB2) have also been observed in CRS patients.