lymphotoxin


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lymphotoxin

 [lim´fo-tok″sin]
a lymphokine containing 171 amino acids, one of the tumor necrosis factors, produced by activated T lymphocytes. It inhibits the growth of tumors by causing lysis or stasis of sensitive cells, and also blocks transformation of cells. Called also tumor necrosis factor β.

lym·pho·tox·in

(lim'fō-tok'sin),
A lymphokine from T lymphocytes that lyses or damages many cell types.

lymphotoxin

(lĭm′fə-tŏk′sĭn)
n.
A lymphokine that is toxic to certain susceptible target cells.

lym·pho·tox·in

(lim'fō-tok'sin)
A lymphokine that lyses or damages many cell types.
References in periodicals archive ?
Following gastric bypass surgery in morbidly obese diabetic patients, MMP-9 and NOM levels dropped, along with the expression of six asthma-related genes including the key factors, interleukin 4, LIGHT, lymphotoxin beta and interleukin 33 in parallel with weight loss and improvements in the status of their diabetes.
Harkins, "Human lymphotoxin. Production by a lymphoblastoid cell line, purification, and initial characterization," Journal of Biological Chemistry, vol.
However, the lymphotoxin [beta] receptor (LTpR) in stromal cells induces processing of p100 via an alternative pathway, which leads to the delayed and sustained liberation of p50-RelB and p52-RelB complex (14).
An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.
Other agents are directed toward new cytokine targets, including IL-6 (tocilizumab), and lymphotoxin pathways (briobacept), as well as other B-cell targets, to include BLyS and APRIL (belimumab, atacicept).
receptor or its ligand, surface lymphotoxin, that act as lymphotoxin-.beta.
Generally, Th1 cells produce IL-2, IFN-[gamma], and lymphotoxin, and are involved mostly in cell-mediated immune reactions, while Th2 cells produce IL-4, IL-5, IL-10, and IL-13, and are commonly associated with strong antibody and allergic immune responses (Cerwenka et al., 1998).
The sequential role of lymphotoxin and B cells in the development of splenic follicles.
Th1 cells secrete IL-2, IFN-[gamma], and lymphotoxin, and are primarily associated with macrophage activation and delayed-type hypersensitivity.
[33.] Selmaj K, Raine CS, Cannella B, Brosnan CF: Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions.
225 (1990a); Gatanaga, et al., Purification And Characterization Of An Inhibitor (Soluble Tumor Necrosis Factor Receptor) For Tumor Necrosis Factor And Lymphotoxin Obtained From The Serum Ultrafiltrates Of Human Cancer Patients, 87 Proc.