Following gastric bypass surgery in morbidly obese diabetic patients, MMP-9 and NOM levels dropped, along with the expression of six asthma-related genes including the key factors, interleukin 4, LIGHT, lymphotoxin
beta and interleukin 33 in parallel with weight loss and improvements in the status of their diabetes.
Harkins, "Human lymphotoxin
. Production by a lymphoblastoid cell line, purification, and initial characterization," Journal of Biological Chemistry, vol.
Multiple roles for tumor necrosis factor-alpha and lymphotoxin
alpha/beta in immunity and autoimmunity.
However, the lymphotoxin
[beta] receptor (LTpR) in stromal cells induces processing of p100 via an alternative pathway, which leads to the delayed and sustained liberation of p50-RelB and p52-RelB complex (14).
An antibody to lymphotoxin
and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.
Other agents are directed toward new cytokine targets, including IL-6 (tocilizumab), and lymphotoxin
pathways (briobacept), as well as other B-cell targets, to include BLyS and APRIL (belimumab, atacicept).
receptor or its ligand, surface lymphotoxin
, that act as lymphotoxin-.beta.
Generally, Th1 cells produce IL-2, IFN-[gamma], and lymphotoxin
, and are involved mostly in cell-mediated immune reactions, while Th2 cells produce IL-4, IL-5, IL-10, and IL-13, and are commonly associated with strong antibody and allergic immune responses (Cerwenka et al., 1998).
The sequential role of lymphotoxin
and B cells in the development of splenic follicles.
Th1 cells secrete IL-2, IFN-[gamma], and lymphotoxin
, and are primarily associated with macrophage activation and delayed-type hypersensitivity.
[33.] Selmaj K, Raine CS, Cannella B, Brosnan CF: Identification of lymphotoxin
and tumor necrosis factor in multiple sclerosis lesions.
225 (1990a); Gatanaga, et al., Purification And Characterization Of An Inhibitor (Soluble Tumor Necrosis Factor Receptor) For Tumor Necrosis Factor And Lymphotoxin
Obtained From The Serum Ultrafiltrates Of Human Cancer Patients, 87 Proc.