44% Lymphoma Spill Table 5: Shows the Number of Various Lymphoreticular
Majority of the cases sent for review were from lymphoreticular
system (n=33), followed by gastrointestinal tract (n=27) and bones and soft tissue (n=21).
Primary non lymphoreticular
malignant neoplasms of the spleen.
vCJD prions have been detected at post-mortem in the lymphoreticular
tissue of appendix, tonsillar and GI lymph node tissue.
Number of immunological and lymphoreticular
effects have been reported in humans and animals exposed to nickel.
Lymphoma and Reticuloendothelial Neoplasms (a) Hodgkin's lymphoma 9650-9667 (not included in this assessment) (b) Non-Hodgkin's lymphoma 9591-9595, 9670-9686, 9688, 9690-9717, 9723 (c) Burkitt's lymphoma 9687 (d) Miscellaneous lymphoreticular
9720, 9731-9764 neoplasms (e) Unspecified lymphoma 9590 126 III.
The gross and microscopic lesions reported in the studied cases are highly suggestive of a viral disease, due to its pathogenicity and affinity for lymphoreticular
and endothelial cells of blood vessels in different vital organs, while bacterial hemorrhagic diseases do not induce lesions on vessels endothelium.
A previous study demonstrated that falsely increased phosphorus values may occur in patients with plasma cell dyscrasias and lymphoreticular
malignancies associated with abnormal immunoglobulin synthesis (2).
Bleomycin is the common antineoplastic antibiotic available in market for the treatment of epidermal neoplasm, as well as lymphoreticular
and other epithelial carcinomas, including squamous cell carcinoma and malignant lymphoma (Jaroszeski et al.
Moreover, the proposed link has been extended to a wide variety of lymphoreticular
and solid organ neoplasms.
MTBE causes increased incidence of Leydig cell testicular tumours in male rats and an increase in leukemia, dysplastic proliferations of lymphoreticular
tissues, and uterine sarcomas in female rats .
Prof DeArmond said: 'All I am trying to do is search for something that would get the protein into the lymphoreticular
system, particularly into the tonsils, and certainly some irritation there, injury or inflammation, might have been one way that these 90-odd people were unlucky.