The QA and PWG pathologists defined lymphoreticular
neoplasms as either malignant lymphomas or mononuclear cell leukemias in order for their results to be more comparable to reporting schemes historically used by the NTP and because these tumors are thought to be of separate cellular origin after differentiation from myeloid stem cells (EPL 2011b, 2011c).
Lymphomas are the diverse and complex group of neoplasms affecting lymphoreticular
system5 and are classified based on cell lineage by 'The Revised Euro- pean American lymphoma' (REAL/WHO) system as : B cell malignancy ,T cell/natural killer malignancy and Hodgkin's lymphoma.6,7 Hodgkin's lymphoma often presents as nodal disease whereas Non-Hodgkin's may also have an extranodal presentation.1,6 The exact etiology of lymphomas is unknown however genetic predisposition, immunodeficiency state like HIV, re- cipients under transplantation and chromosomal trans- location has been implicated.8
Majority of the cases sent for review were from lymphoreticular
system (n=33), followed by gastrointestinal tract (n=27) and bones and soft tissue (n=21).
Primary non lymphoreticular
malignant neoplasms of the spleen.
2720 Adelusola, K., Sabageh, D.O., Ukah, C.O., Lymphoreticular
diseases in Nigeria.
vCJD, however, is present not only in the blood but also in lymphoreticular
tissues such as the tonsils.
Immunodeficiency or malignancy (especially malignancies of lymphoreticular
tissues), systemic lupus erythematosus (SLE), and other types of collagen vascular diseases are the most common causes of secondary AIHA in children (3).
Botha A, Taylor I Haemopoeitic and lymphoreticular
systems In: Majid A, Kingsnorth A 2003 Fundamentals of Surgical Practice London, Greenwich Medical Media Ltd
The effects on the immune system include cellular and tissue manifestations throughout the 'lymphoreticular
' system--lymph nodes (LN), spleen, extranodal lymphoid tissues, bone marrow and peripheral blood.
vCJD prions have been detected at post-mortem in the lymphoreticular
tissue of appendix, tonsillar and GI lymph node tissue.