lymphoplasmacytic lymphoma

lymphoplasmacytic lymphoma

lymphoplasmacytic lymphoma/Waldenstrm macroglobulinemia is characterized by the presence of a diffuse proliferation of small mature B lymphocytes, plasmacytoid lymphocytes, and plasma cells; the cells show surface Ig (usually IgM), B-cell-associated antigens, and are CD23 and CD10 negative. The t(9;14) chromosomal translocation has been found in 50% of all lymphoplasmacytic lymphoma cases. Clinical course is usually indolent, but may be associated with hyperviscosity syndrome due to excess IgM in the blood.
See also: Waldenström macroglobulinemia.
Synonym(s): immunocytoma
References in periodicals archive ?
Patients with small lymphocytic leukemia, lymphoplasmacytic lymphoma / Waldenstroms macroglobulinemia and marginal zone lymphoma were also enrolled in the study and included in the safety analysis.
Lymphoplasmacytic lymphoma (LPL) is a rare type of non-Hodgkin lymphoma usually involving bone marrow, and less frequently, the lymph nodes and spleen.
MYD88 mutations are found in most cases of lymphoplasmacytic lymphoma (16), and both MYD88 and CD79B mutations are common in the more aggressive activated B-cell molecular subtype of DLBCL.
1 Aplastic anaemia 1 2 Acute lymphoblastic leukemia 2 3 Acute myeloid leukemia 1 4 Multiple myeloma 13 5 Myelodysplastic syndrome 3 6 Myeloproliferative neoplasm 2 7 Immune thrombocytopenic purpura 2 8 Lymphoproliferative Disorder Chronic lymphoblastic leukemia 1 Lymphoplasmacytic lymphoma 1 Non Hodgkin's lymphoma 2 TOTAL 28 SL.
Bone marrows aspirate and trephine biopsy findings in lymphoplasmacytic lymphoma.
7) Lymphoblastic leukemia/ lymphoma 1 0 Lymphoplasmacytic lymphoma 4 0 Mantle cell lymphoma 7 0 Posttransplant lymphoproliferative disorder, polymorphic 1 0 Splenic marginal zone lymphoma 1 0 Unclassified 2 1 (50.
The three positive opinions are for the treatment of chronic lymphocytic leukaemia (CLL) / small lymphocytic lymphoma (SLL), mantle cell lymphoma (MCL) and lymphoplasmacytic lymphoma (Waldenstrms macroglobulinaemia, MG).
These included 25 cases of MCL, 41 cases of CLL/SLL, 3 cases of hairy cell leukemia, 4 of follicular lymphoma, 5 of diffuse large B-cell lymphoma, 2 of Burkitt lymphoma, 1 of prolymphocytic leukemia B-cell type, 1 of lymphoplasmacytic lymphoma, 5 of acute lymphoblastic leukemia, and 10 cases of marginal zone lymphoma.
Splenic EBV-associated IPT should also be differentiated from inflammatory myofibroblastic tumor (IMT), Hodgkin lymphoma, interdigitating dendritic cell sarcoma, conventional FDC sarcoma, sclerosing angiomatoid nodular transformation of the spleen (SANT), lymphoplasmacytic lymphoma, EBV-positive lymphoproliferative disorder, and EBV-associated smooth muscle tumor.
Lymphoplasmacytic lymphoma (LPL) is a neoplasm of small B lymphocytes, plasmacytoid lymphocytes, and plasma cells.
3) HGAL and LMO2 were uniformly absent in cases classified as marginal zone lymphoma (MZL), chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma (MCL), and lymphoplasmacytic lymphoma (LPL).