We are currently enrolling patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), lymphoplasmacytic lymphoma
(LPL) and marginal zone lymphoma (MZL) in the third cohort.
The highest familial risk of blood cancer was for certain Hodgkin lymphomas, lymphoplasmacytic lymphoma
and mantle cell lymphoma.
To further investigate the possible resemblance of MYD88-mutated POAMZL to lymphoplasmacytic lymphoma
, we evaluated the plasmacytic differentiation in our cohort and showed that 47% of POAMZLs exhibited subtle plasmacytic differentiation, and the features were similar between the MYD88-mutated and nonmutated cases.
Steady advances in the field of bone marrow biopsy in the last few years have facilitated the accurate diagnosis of complex indications such as Hodgkin's lymphoma, lymphoplasmacytic lymphoma
and other cancers of lymph and vascular systems.
The prognosis of Schnitzler's syndrome is linked to the evolution of the lymphoproliferative disorder (15-20%), whether lymphomas, including lymphoplasmacytic lymphoma
, Richter-type lymphoma, marginal zone lymphoma, myeloma or Waldenstrom's disease.
Non-Hodgkin lymphoma of the breast is exceedingly rare; the majority diagnosed are of B-cell origin including diffuse large B-cell lymphoma, extranodal marginal zone lymphoma, follicular lymphoma, primary effusion lymphoma, and lymphoplasmacytic lymphoma
McPhail, "Novel immunophenotypic features of marrow lymphoplasmacytic lymphoma
and correlation with Waldenstrom's macroglobulinemia," Modern Pathology, vol.
MYD88 mutations are found in most cases of lymphoplasmacytic lymphoma
(16), and both MYD88 and CD79B mutations are common in the more aggressive activated B-cell molecular subtype of DLBCL.
1 Aplastic anaemia 1 2 Acute lymphoblastic leukemia 2 3 Acute myeloid leukemia 1 4 Multiple myeloma 13 5 Myelodysplastic syndrome 3 6 Myeloproliferative neoplasm 2 7 Immune thrombocytopenic purpura 2 8 Lymphoproliferative Disorder Chronic lymphoblastic leukemia 1 Lymphoplasmacytic lymphoma
1 Non Hodgkin's lymphoma 2 TOTAL 28 SL.
Bone marrows aspirate and trephine biopsy findings in lymphoplasmacytic lymphoma
. Am J Hematol 2011;86:311-2.
A form of reactive mast cell hyperplasia, which is observed in other hematologic neoplasms, such as lymphoplasmacytic lymphoma
and hairy cell leukemia (HCL) must be excluded .