About Waldenstrom's macroglobulinemia WM (a clinically recognized subset of lymphoplasmacytic lymphoma
, or LPL) is a slow-growing and rare blood cancer that most commonly originates from B cells, a type of white blood cell (lymphocyte) that develops in the bone marrow.
If both cell populations are part of the same clone they could represent marginal zone lymphoma or lymphoplasmacytic lymphoma
, (9,10) whereas if they are separate clones, they may indicate a low-grade B-cell lymphoma and a concurrent plasma-cell neoplasm, such as monoclonal gammopathy of undetermined significance.
7) Lymphoblastic leukemia/ lymphoma 1 0 Lymphoplasmacytic lymphoma
4 0 Mantle cell lymphoma 7 0 Posttransplant lymphoproliferative disorder, polymorphic 1 0 Splenic marginal zone lymphoma 1 0 Unclassified 2 1 (50.
These included 25 cases of MCL, 41 cases of CLL/SLL, 3 cases of hairy cell leukemia, 4 of follicular lymphoma, 5 of diffuse large B-cell lymphoma, 2 of Burkitt lymphoma, 1 of prolymphocytic leukemia B-cell type, 1 of lymphoplasmacytic lymphoma
, 5 of acute lymphoblastic leukemia, and 10 cases of marginal zone lymphoma.
The most common underlying lymphoproliferative or plasma cell disorders included multiple myeloma (32%), lymphoplasmacytic lymphoma
(24%), paraproteinemia/monoclonal gammopathy of undetermined significance (21%), and B-cell lymphomas (15%).
The differential diagnoses of a lymphoplasmacytic or lymphoplasmacytoid infiltration in the bone marrow include at least 3 neoplastic conditions: lymphoplasmacytic lymphoma
(LPL) (also called immunocytoma or Waldenstrom macroglobulinemia), marginal zone lymphoma (MZL) with plasmacytic differentiation, and CLL with plasmacytic differentiation.
(LPL) is a chronic, lymphoproliferative neoplasm characterized by small B lymphocytes, plasmacytoid lymphocytes, and plasma cells typically involving the bone marrow, lymph nodes, and spleen.
Waldenstrom's macroglobulinemia; macroglobulinemia - primary; Lymphoplasmacytic lymphoma
is defined as a neoplasm of small B lymphocytes, plasmacytoid lymphocytes, and plasma cells that primarily involves the bone marrow and less commonly the lymph nodes and spleen.
7) Occasionally, as in this case, plasma cells are the predominant cell type, potentially leading to confusion with other hematolymphoid neoplasms, such as plasmacytoma and lymphoplasmacytic lymphoma
WM is also called lymphoplasmacytic lymphoma
because it occurs when abnormal lymphoplasmacytic cells multiply out of control, producing large amounts of a protein called monoclonal immunoglobulin M.
This multi-institutional trial included patients with DLBCL (phase 1, 4 patients; phase 2, 23 patients), follicular lymphoma (FL; phase 1, 4 patients; phase 2, 21 patients), mantle cell lymphoma (phase 1, 3 patients; phase 2, 9 patients), marginal zone lymphoma (phase 2, 2 patients), lymphoplasmacytic lymphoma
(phase 2, 1 patient), and chronic lymphocytic leukemia (CLL; phase 1, 2 patients; phase 2, 11 patients).