He was slightly
lymphopenic (0,8 x [10.sup.9]/L) and had low levels of CD4+ cells (177 x [10.sup.6]/L) with an inversed CD4/CD8 ratio of 0,63.
BB rats develop diabetes at 8-16 weeks of age and have severe insulin deficiency, but despite not showing the gender differences seen in NOD mice, the rats are
lymphopenic [27], which is not a characteristic of T1D in humans.
Subsequently, he was switched to pyrimethamine, leucovorin, and atovaquone as secondary prophylaxis for toxoplasma infection while he was
lymphopenic during ongoing maintenance chemotherapy.
Peggs et al., "Tumor-reactive [CD4.sup.+] T cells develop cytotoxic activity and eradicate large established melanoma after transfer into
lymphopenic hosts," Journal of Experimental Medicine, vol.
(5) They found through meticulous electron microscopic analyses that, whereas about 40% of the lymphocytes interacting with the HEV ECs are in the process of transmigrating in normal mice, about 90% of the interacting cells are in the process of transmigrating in
lymphopenic mice in which circulating lymphocytes were depleted by thoracic duct cannulation, (5) indicating that lymphocyte transmigration is upregulated when the circulating lymphocyte level is low.
Good, "Immunological reconstitution of sex-linked
lymphopenic immunological deficiency," Lancet, vol.
Lim et al., "CD4+VEGFR1HIGH T cell as a novel Treg subset regulates inflammatory bowel disease in
lymphopenic mice," Cellular and Molecular Immunology, vol.
Even more exciting is the fact that idiopathic T cell
lymphopenic conditions have been discovered through this testing which undoubtedly represent new genetic defects heretofore unknown.
Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in
lymphopenic hosts after conversion into Th1 cells.
[sup][2],[4],[6],[8],[10] Ten leukopenic patients were associated with low CD4+ counts of which 8 were
lymphopenic and two, neutropenic in the present study.
I was also progressively
lymphopenic and had remarkable responses to parenteral vitamins, especially vitamin B12 (improved mental clarity) and folic acid (resolution of progressive lymphopenia).