lymphomatoid papulosis


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lym·pho·ma·toid pa·pu·lo·sis

a chronic papular and ulcerative variant of pityriasis lichenoides et varioliformis acuta characterized by dermal perivascular infiltration by atypical T lymphocytes suggestive of a lymphoma; it is usually benign, but transformation to lymphoma has been reported.

lymphomatoid papulosis

A roccidig papular eruption of the skin that histologically resembles lymphoma; although most lesions behave in an indolent fashion, gene rearrangement studies demonstrate a T-cell clonal expansion (10–20% evolve to T-cell lymphoma); acral and truncal distribution.

DiffDx, benign
Arthropods, infectious granulomas (TB, fungal), leukocytoclastic vasculitis, PLEVA (pityriasis lichenoides et variolis acuta), pseudolymphoma, scabies.

DiffDx, uncertain
Langerhans cell histiocytosis.

DiffDx, malignant
Acute lymphoblastic lymphoma, Merkel cell carcinoma, mycosis fungoides.

lymphomatoid papulosis

 A benign recurring papular eruption of the skin which histologically resembles lymphoma; although most lesions are indolent, gene rearrangement studies demonstrate a T cell clonal expansion; 10-20% evolve toward T-cell lymphoma
References in periodicals archive ?
Spectrum of CD30+ lymphoid proliferations in the eyelid lymphomatoid papulosis, cutaneous anaplastic large cell lymphoma, and anaplastic large cell lymphoma.
Lymphomatoid papulosis in children: a retrospective cohort study of 35 cases.
The latter include proliferations related to the human papillomaviruses, (1) as well as Langerhans cell histiocytosis, (2) "large plaque parapsoriasis," (3) selected cutaneous lymphoid "hyperplasias," (4) lymphomatoid papulosis, (5,6) the spectrum of fibromatoses and melanocytic nevi, (7,8) and spindle cell hemangioendothelioma-hemangioma.
CD30+ diseases: anaplastic large-cell lymphoma and lymphomatoid papulosis.
lymphoproliferative disorders Primary cutaneous anaplastic large cell lymphoma Lymphomatoid papulosis Subcutaneous panniculitis-like T-cell lymphoma Extranodal NK/T-cell lymphoma, nasal type Primary cutaneous peripheral T-cell lymphoma, unspecified Primary cutaneous aggressive epidermotropic [CD8.
The study includes patients with relapsed or refractory CD30-expressing cutaneous T-cell disease, including cutaneous ALCL, transformed mycosis fungoides and lymphomatoid papulosis.
The study was recently amended to include two other related CD30-positive indications: transformed mycosis fungoides and lymphomatoid papulosis (LyP).