lymphomatoid papulosis


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lym·pho·ma·toid pa·pu·lo·sis

a chronic papular and ulcerative variant of pityriasis lichenoides et varioliformis acuta characterized by dermal perivascular infiltration by atypical T lymphocytes suggestive of a lymphoma; it is usually benign, but transformation to lymphoma has been reported.

lymphomatoid papulosis

A roccidig papular eruption of the skin that histologically resembles lymphoma; although most lesions behave in an indolent fashion, gene rearrangement studies demonstrate a T-cell clonal expansion (10–20% evolve to T-cell lymphoma); acral and truncal distribution.

DiffDx, benign
Arthropods, infectious granulomas (TB, fungal), leukocytoclastic vasculitis, PLEVA (pityriasis lichenoides et variolis acuta), pseudolymphoma, scabies.

DiffDx, uncertain
Langerhans cell histiocytosis.

DiffDx, malignant
Acute lymphoblastic lymphoma, Merkel cell carcinoma, mycosis fungoides.

lymphomatoid papulosis

 A benign recurring papular eruption of the skin which histologically resembles lymphoma; although most lesions are indolent, gene rearrangement studies demonstrate a T cell clonal expansion; 10-20% evolve toward T-cell lymphoma
References in periodicals archive ?
aggressive T-cell lymphoma, and type D lymphomatoid papulosis, is epidermotropism.
The cutaneous T cell lymphomas (CTCL) include diverse malignancies: mycosis fungoides (MF), Sezary syndrome, lymphomatoid papulosis (LyP), anaplastic large-cell lymphoma (ALCL) and many less known varieties.
Lymphomatoid papulosis is a rare, chronic, and benign papulonodular or papulonecrotic skin disorder.
In addition, many types of cutaneous lymphoma can have similar histomorphologic features--for example, some tumoral lesions of mycosis fungoides (MF) with large cell transformation cannot be reliably distinguished from anaplastic large cell lymphoma or lymphomatoid papulosis by hematoxylin-eosin sections or even IHC.
Kontos AP, Kerr HA, Malick F, Fivenson DP, Lim HW, Wong HK: 308-nm excimer laser for the treatment of lymphomatoid papulosis and stage IA mycosis fungoides.
At the T-Cell Lymphoma Forum in January 2012, interim data were presented from a phase II investigator-sponsored trial in CD30-positive CTCL patients, including lymphomatoid papulosis, primary cutaneous anaplastic large cell lymphoma (pcALCL) or MF.
298,299) CD30 positivity alone does not imply a diagnosis of lymphomatoid papulosis or ALCL.
Incorrect diagnoses occur mainly because many diseases are mistakenly diagnosed as spider bites, including many conditions much more prevalent and serious, such as staphylococcal or streptococcal infection, herpes simplex and zoster, erythema multiforme, diabetic ulcer, fungal infection, pyoderma gangrenosum, lymphomatoid papulosis, syphilis, and Lyme disease.
Lymphomatoid papulosis turns out to be malignant in 10%-20% of cases.
Lack of c-kit (CD117) expression in CD30+ lymphomas and lymphomatoid papulosis.
Lymphomatoid papulosis may mimic acute lichenoid pityriasis, mycosis fungoides, or anaplastic large cell lymphoma.