lymphokine


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lymphokine

 [lim´fo-kīn]
any of various soluble protein mediators released by sensitized lymphocytes on contact with antigen, and believed to play a role in macrophage activation, lymphocyte transformation, and cell-mediated immunity. It regulates immune responses through differentiation, amplification, and inhibition of cell functions. Lymphokines may also have a cytotoxic effector function. Used as biologic response modifiers in the treatment of cancer.

lym·pho·kine

(lim'fō-kīn),
Hormonelike peptide, released by activated lymphocytes, which mediates immune response; a cytokine obtained from lymphocytes.
[lymphocyte + G. kineō, to set in motion]

lymphokine

(lĭm′fə-kīn′)
n.
Any of various soluble substances, released by sensitized lymphocytes on contact with specific antigens, that act by stimulating activity of monocytes and macrophages.

lymphokine

An older term for what is now designated interleukin-2 (IL2).

lym·pho·kine

(lim'fō-kīn)
Hormonelike peptide, released by activated lymphocytes, which mediates immune response; a cytokine obtained from lymphocytes.
[lymphocyte + G. kineō, to set in motion]

lymphokine

a soluble mediator released by lymphocytes on contact with specific antigens.
References in periodicals archive ?
There are several different types of cytokines such as monokines (cytokines produced by monocytes and macrophages), lymphokines (cytokines produced by lymphocytes), inflammatory peptides (cytokines produced by neutrophils), and vasoactive amines (cytokines produced by platelets and mast cells).
TNF, factor de necrosis tumoral; NK, natural killer o asesina natural; K, killer o asesina; LAK, lymphokine activated killer o asesina activada por linfoquinas.
Helper T-cells produce powerful chemicals, called lymphokines, that mobilize other immune system substances and cells.
Research shows that ozone depletion also may exacerbate the effect of climate change on infectious disease as well as cause immunosuppression by altering T-cells and lymphokine production.
Lymphokine mediated regulation of the proliferative response of clone of T helper 1 and T helper 2 cells.
CLMF synergistically induces with low concentrations of IL-2 the cytolytic activity of Lymphokine Activated Killer (LAK) cells, and CLMF is capable of stimulating T-cell growth.
"We've found a particular type of cytokine called lymphokine that causes heterophils to come to where the bacteria are and devour them," says Kogut.
Antigen-activated T-cell multiplication has long been associated with the lymphokine IL-2's role in the immune response (Harrington et al., 1993).
A diffusible lymphokine produced by CD8+ T lymphocytes suppresses HIV replication.
After these cells are primed for combat against cancer by exposure to the lymphokine called interleukin 2, a stimulant of T-cell growth, they are put back into the patient.
If we are to avoid wasting precious resources on therapies looking for diseases to treat (as may be the case for interleukin-2, a lymphokine developed for treating kidney cancer), we need clearer guidelines of what constitutes an indication for therapy and how much society is willing to invest in underwriting treatments for rare disorders, or unproven remedies for treating common ones.