A second sample, obtained 10 months after disease onset, revealed a light perivascular lymphohistiocytic
infiltrate, as seen in erythema annulare centrifugum.
Histologic examination revealed a lymphohistiocytic
and heterophilic splenitis with multifocal thrombosis and necrosis, multifocal necrotizing hepatitis, and multifocal exocrine pancreas necrosis.
Sometimes a biopsy is performed and it reveals a dense lichenoid lymphohistiocytic
infiltrate with a strong cytoplasmic immunopositivity for beta-defensin-4 in the stratum corneum, granulosum, and spinosum.
The WHO Classification of Tumours of Haematopoietic and Lymphoid Tissue (36) describes several histologic variants, including the common variant, lymphohistiocytic
variant, small cell variant, Hodgkin-like variant, and composite variant.
The histopathological examination showed normal stratum corneum, focal areas of atrophy in stratum spinosum, effaced rete ridges, hyperpigmented basal layer, eosinophilic amorphous collagen fibres in dermis, perivascular and periappendageal lymphohistiocytic
9] There is lymphohistiocytic
infiltration of virtually all organs with more profound immune deficiency.
Five of the 12 patients whose post-treatment biopsy showed complete clearance of pretreatment granulomas leaving only a lymphohistiocytic
inflammatory infiltrate (case no.
Histopathological of the edge of an ulcer on the dorsum demonstrated dense lymphohistiocytic
inflammatory infiltrate with plasma and mast cells, in addition to neutrophils and granuloma formation; hyperplastic skin surrounded with areas of pseudoepitheliomatous pattern.
Light microscopic findings of melasma include increased deposits of melanin in the epidermis and dermis, or both when compared with adjacent normal skin and a mild perivascular lymphohistiocytic
However, mild perivascular lymphohistiocytic
infiltrate in the dermis has also been reported (1).
Reduced serum ferritin glycosylation is not pathognomonic for AOSD and can occur in other inflammatory diseases, certain infections and carcinomas, hepatic disease, and hemophagocytosis lymphohistiocytic
The pathological examination (Fig-4) showed chronic granulomatous inflammation with areas of necrosis, epithelioid granulomas with Langhans giant cells and lymphohistiocytic
aggregates suggestive of tuberculosis.