Small round blue cells with lymphoglandular bodies in the background are suggestive of a lymphoproliferative disorder.
They usually have a moderate amount of cytoplasm that can be clear to eosinophilic to basophilic with lymphoglandular bodies in the background.
In this case the absence of lymphoglandular
bodies and the presence of large clusters of cohesive cells and a negative stain for LCA ruled out a lymphoma.
3,13) These carefully adjudicated slides did have the features of ACC, but as in day-to-day practice, diagnosis requires careful study, identification of the stromal component, and recognition of the absence of lymphoglandular
Extracellular and Connective Tissue Components Background stroma Neuropil Neuroblastoma Desmoplasia Desmoplastic small cell tumor Myxoid Liposarcoma, embryonal rhabdomyosarcoma Calcifications Neuroblastoma, synovial sarcoma, and MNST Lymphoglandular
Non-Hodgkin lymphoma bodies Other elements Neuronal cells Neuroblastoma, ectomesenchymoma Rhabdomyoblasts Rhabdomyosarcoma Cross-striations Rhabdomyosarcoma Blastema/ Nephroblastoma, pleuropulmonary epithelium blastoma Abbreviation: MNST, malignant nerve sheath tumor.
In addition, the presence of lymphoglandular bodies in the background was appreciated (Figure 1, A).
Like the smears of IPAS, those prepared from aspirations of lymphoma may contain a lymphoglandular bodies in the background.
The intraoperative touch/smear preparations showed marked discohesion and a relatively heterogeneous population of predominantly small, mature-appearing lymphoid cells with many lymphoglandular
bodies (cytoplasmic fragments) in the background, helping to remove a malignant epithelial process from the differential diagnosis.