lymphoepithelioma


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nasopharyngeal carcinoma

A rare (in the West) malignancy which is endemic in regions of southern China—where it comprises up to 18% of cancers—as well as in southeast Asia. It is linked to EBV infection, diets high in nitrosamines and inhaled carcinogens. It is more common in males and has a peak incidence of age 40 to 50.

DiffDx
Lymphoma (DLCBL, Hodgkin's), reactive lymphoid proliferation, sarcomas.

Management
Radiotherapy, chemotherapy.

Prognosis
Stage dependant; 5-year survival is 55%.

Nasopharyngeal carcinomas (WHO, 2005)
- Keratinising squamous cell carcinoma
- Non keratinsing carcinoma
  • Differentiated
  • Undifferentiated
- Basaloid squamous cell carcinoma
- Nasopharyngeal cancer, staging
  • Stage I—Lesion confined to nasopharynx.
  • Stage II
    A) Lesion extends to oropharynx and/or nasal fossa.
    B) Lesion extends to nearby lymph nodes or to parapharyngeal region.
  • Stage III—Lesion spread to lymph nodes on both sides of the neck or nearby bones or sinuses.
  • Stage IV
    A) Spread beyond nasopharynx to other areas in head; possible spread to regional lymph nodes.
    B) Spread beyond nasopharynx to other areas in head and to lymph nodes above clavicle, or are ≥ 6 cm in greatest dimension.
    C) Metastasised.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

lymphoepithelioma

Undifferentiated nasopharyngeal carcinoma A CA with a marked lymphocytic component Types–Schmincke type Diffuse mixing of epithelial and lymphoid elements, making the lesion difficult to distinguish from lymphoma, since the epithelial cells may mimic lymphoblasts or the lacunar cell variants of Reed-Sternberg cells Regaud type Cohesive carcinoma cell aggregates that are large enough to make the epithelial nature of the tumor obvious Diagnosis Immunoperoxidase stains for cytokeratin
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

lym·pho·ep·i·the·li·o·ma

(lim'fō-ep'i-thē'lē-ō'mă)
A poorly differentiated radiosensitive squamous cell carcinoma involving lymphoid tissue in the region of the tonsils and nasopharynx; metastasizes early to cervical lymph nodes.
[lympho- + epithelium + -oma, tumor]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

Schmincke,

Alexander, German pathologist, 1877-1953.
Schmincke tumor - Synonym(s): lymphoepithelioma
Medical Eponyms © Farlex 2012

lym·pho·ep·i·the·li·o·ma

(lim'fō-ep'i-thē'lē-ō'mă)
A poorly differentiated radiosensitive squamous cell carcinoma involving lymphoid tissue in the region of the tonsils and nasopharynx; metastasizes early to cervical lymph nodes.
[lympho- + epithelium + -oma, tumor]
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
Although the association between Epstein-Barr virus and lymphoepithelioma of the nasopharynx and other tissues (lung, stomach, thymus, and salivary gland) is already proved, in the bladder, the hybridization with Epstein-Barr virus encoded RNA has been reported to be consistently negative in different series [6, 9, 10].
Types 2 and 3 may be accompanied by an inflammatory infiltrate of lymphocytes, plasma cells, and eosinophils, which are abundant, giving rise to the term lymphoepithelioma and which we had only one case.
A final diagnosis of lymphoepithelioma like carcinoma of kidney pT3 N2a cM0 was rendered.
Lymphoepithelioma is a common malignant tumour of the nasopharynx.
We report a case of unilateral tonsillar lymphoepithelioma with extension into the ipsilateral parapharyngeal space, and we review the clinical, histologic, and radiographic findings of the case.
This undifferentiated carcinoma is made up of cells of varying morphology, and it frequently contains clumps of benign T cells intermixed within the tumor mass; as a result, it is also called a lymphoepithelioma. (5) Type III tumors account for 95% of all cases in endemic areas and 60% of cases in North America.
The histologic features of the right nasopharyngeal specimen were consistent with a typical nasopharyngeal carcinoma of the lymphoepithelioma subtype.
(3) Morphologically, MLEL resembles lymphoepithelioma (undifferentiated nasopharyngeal carcinoma with lymphoid stroma), and it is often difficult to distinguish MLEL from metastatic nasopharyngeal carcinoma of the salivary gland.
(44,49,50) This explains this tumor's previous designation as lymphoepithelioma or lymphoepithelioma-like carcinoma.
Adenocarcinomas, sarcomas, and lymphoepitheliomas should be considered separately.
Human papilloma virus (HPV) DNA has been shown in the tumor cells of lymphoepitheliomas of the breast, (25) and transcriptionally active HPV has been shown by in situ hybridization in LELCs of the oropharynx.