lymphocytotoxicity assay

lymphocytotoxicity assay

A complement-mediated assay commonly used in HLA typing laboratories, which tests for cytotoxic antibodies in the serum of a potential recipient that may react with the lymphocytes of a potential donor. See Human leukocyte antigen, Mixed lymphocyte culture.
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Analysis of a posttransfusion serum sample from the patient did not reveal the presence of any anti-HLA antibody activity, as tested by sensitive antiglobulin lymphocytotoxicity assays.[12] This method has been found to be comparable in sensitivity to the flow cytometry method.[12] Limited sample size and availability precluded the use of other comparable methods (eg, enzyme-linked immunosorbent assay).