lymphocytic hypophysitis

lym·pho·cy·tic hy·po·phy·si·tis

an acute anterior pituitary lymphocytic reaction characterized clinically by signs and symptoms of anterior pituitary insufficiency; probably an autoimmune disorder because antipituitary antibodies are present in the serum.

lymphocytic hypophysitis

A relatively rare autoimmune disease in which the pituitary gland is infiltrated and damaged by lymphocytes, esp. during pregnancy or the postpartum period. Imaging studies of the pituitary gland show massive enlargement.. Imaging studies of the pituitary gland show massive enlargement. Hormone deficiencies, or in some cases, hyperprolactinemia, can occur.
Synonym: autoimmune hypophysitis
See also: hypophysitis
References in periodicals archive ?
Therefore, as in our case initially, the majority of reported cases are treated as lymphocytic hypophysitis [3, 4] (Table 2).
Menet et al., "Pituitary germinoma presenting as a pseudotumoral lymphocytic hypophysitis in a man," Annales d'Endocrinologie, vol.
On histology, IgG4-RH is essentially similar to lymphocytic hypophysitis, which is the most prevalent type of primary hypophysitis, besides massive IgG4-positive plasmacyte infiltration [2].
The sequence of anterior pituitary deficiencies in IgG4-RH patients is slightly different from primary lymphocytic hypophysitis patients in a recently published Chinese study (FSH/LH > TSH > ACTH > IGF-1 axis deficiency) [14].
Combined granulomatous and lymphocytic hypophysitis presenting as pituitary incidentaloma in a middle-aged woman.
Case report and bibliographic review about lymphocytic hypophysitis in childhood
Infectious or inflammatory causes include meningitis, lymphocytic hypophysitis and granulomatous inflammations such as sarcoidosis, Wegener's granulomatosis.
His findings reveal eight are suffering from lymphocytic hypophysitis - which usually affects just one in 500million men.
Autoimmune hypophysitis ultimately can give the picture of empty sella on pituitary imaging and cannot be ruled out at present, although GH deficiency is considered to be less common in lymphocytic hypophysitis and pituitary stalk was not thickened in the present patient (12,14).
Lymphocytic hypophysitis, the most frequent of inflammatory processes affecting the pituitary, characteristically occurs in late pregnancy or shortly after delivery.
Lymphocytic hypophysitis with central diabetes insipidus and consequent panhypopituitarism preceding a multifocal, intracranial germinoma in a prepubertal girl.

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