17) These associated disorders include autoimmune thyroid disease (AITD), chronic lymphocytic gastritis producing pernicious anemia, and celiac disease.
Therefore many physicians will routinely screen their patients with type I diabetes for AITD by testing for thyroperoxidase (TPOA) and thyroglobulin (TGA) autoantibodies, and will screen for chronic lymphocytic gastritis by testing for gastric parietal cell autoantibodies or intrinsic factor autoantibodies.
18) If a type I diabetes patient has either AITD or chronic lymphocytic gastritis, adrenal autoimmunity should be sought by screening for adrenal cell cytoplasmic autoantibodies or autoantibodies to the enzyme 21-hydroxylase.
A diagnosis of lymphocytic gastritis can only be made on histology, but many patients have the endoscopic features of varioliform gastritis with mucosal nodules, chronic persistent erosions and thickened mucosal folds.
Lymphocytic gastritis may be found in association with coeliac disease (glutensensitive enteropathy), Menetrier's disease (hypertrophic gastropathy characterised by a hypertrophic gastric mucosa with convoluted, thickened mucosal folds and protein-losing enteropathy), as an abnormal response to HP infection or NSAID use, or in association with lymphocytic/collagenous colitis.
4,8) There have been reports of adult patients with collagenous gastritis having associated lymphocytic gastritis, lymphocytic colitis, ulcerative gastritis, (8) or an underlying autoimmune disease such as Sjogren syndrome.
11) In addition to its association with collagenous gastritis and celiac disease, collagenous sprue has been seen in patients with collagenous colitis, lymphocytic colitis, lymphocytic gastritis, and ulcerative jejunitis.
Associated gastrointestinal diseases include celiac disease (20%), lymphocytic colitis, collagenous sprue, and lymphocytic gastritis.
The association of gastric carcinoma with lymphocytic gastritis
has not to our knowledge been reported before.
may be found in association with coeliac disease (gluten - sensitive enteropathy), Menetrier's disease (hypertrophic gastropathy characterised by a hypertrophic gastric mucosa with convoluted, thickened mucosal folds and protein-losing enteropathy), as an abnormal response to HP infection or NSAID use, or in association with lymphocytic/collagenous colitis.
A thickened (>10 [micro]m) subepithelial collagen band with entrapped capillaries, fibroblasts, and inflammatory cells was seen in the stomach, associated with lymphocytic gastritis.
Lymphocytic gastritis, first described by Haot and colleagues (9) in 1988, is characterized histologically by intra-epithelial lymphocytosis with at least 25 lymphocytes/100 epithelial cells accompanied by chronic inflammation in the lamina propria.