Need to remember that lympho- proliferative disorders can mimic rheumatological disorders in clinical practice.
High grade tumors are rare, the most common grade identified is interme- diate, followed by low grade lesions.5 Falicinia et al reported three children with non-Hodgkin's lympho- ma who had joint swelling at the onset of their disease.4 Takasaki et al reported a patient with Diffuse large B cell non-Hodgkin's lymphoma who developed multiple bone lesions and hypercalcemia.
Angiogenesis the sprouting of new capillaries is required for the development of the vascular system and consequently the growth of vertebrates.1Vascular endothelial growth factor (VEGF) is a pivotal regulator of angiogenesis and is suggested to play an important role in tumor growth and dis- semination.23 Besides being a tumor growth-pro- moting factor VEGF is also characterized as an in- flammatory molecule.4 It is synthesized by a variety of inflammatory cells including endothelial cells megakaryocytes5 granulocytes6 activated lympho-
cytes7 and macrophages8 and may be released from these cells following activation.9 Thereby VEGF may contribute to local hyperpermeability of trau- matized or inflamed tissue as well as induce revas- cularization of the inflamed area.
Bi- opsy of palatal lesion showed sheets of large lympho-
cytes intermixed with large amount of inflammatory cells.
and mono-cytosis,###Basir elat (2011)
HL is classified according to the WHO Classifi- cation, which is the reviewed REAL classification in- to a) Classical Hodgkin's lymphoma, which includes Nodular Sclerosis, Lymphocyte Depletion, Lympho-
cyte Rich and Mixed Cellualrity HL and b) Lympho-
cyte Predominance as a separate entity.3
The morphologic and immunohistochemical findings in harbor seals from German waters during the recent morbillivirus epidemic in northwestern Europe closely resembled those observed in 1988 (5, 11-13) and confirmed the epithelio-, lympho-
and neurotropism of the PDV.