Also found in: Dictionary, Thesaurus, Wikipedia.
Related to lymphangiography: lymphangiectasis




Lymphangiography, or lymph node angiogram, is a test which utilizes x-ray technology, along with the injection of a contrast agent, to view lymphatic circulation and lymph nodes for diagnostic purposes.


The lymphatic system is a one way circulation that channels tissue fluid back into the heart. The watery fluid called lymph seeps out of the blood into tissues, and while journeying back to the heart, it picks up germs, cancer cells, and some waste products. Lymph passes through the lymph nodes, which are major arsenals of immune defense that attack germs carried in the lymph. Cancer cells are also subject to attack in lymph nodes.
Cancers of the lymph system, such as Hodgkin's disease and non-Hodgkin's lymphomas, spread throughout the body. Treatment often depends upon finding all the disease and directing radiation to each location. Planning other kinds of treatment, such as surgery or chemotherapy, may also require that the full extent of the disease be known.
The lymphatic circulation may become clogged by infection, injury, or several other types of cancer that have spread through lymphatic channels. Swelling, sometimes massive, can result from blocked lymphatics. The most outstanding example of this is the tropical disease filariasis, which results in the swelling of the legs termed elephangiasis.
Lymphangiography gives precise information on the extent and location of lymph vessels and lymph nodes. Oftentimes, it is performed to evaluate the extent of a lymphatic cancer. Rarely, it is a tool, which aids surgeons attempting to reconstruct the lymphatics.


Lymphangiography should not be performed on patients with dye or shellfish allergies or on patients with chronic lung disease, kidney disease, heart disease, or liver disease.


A lymphangiogram begins by injecting a blue dye into a hand or foot. The lymph system picks up dye, which in turn will highlight the lymph vessels. This process may take a full day. When the lymphatic channel is clearly visible, the radiologist will insert an even tinier needle into that vessel and inject a contrast agent. X rays outline the journey of the contrast agent as it travels to the heart through lymph vessels and nodes.


Unless a dye allergy is suspected, no special preparation is need. If an allergy is suspected, a non-ionic contrast agent can be administered instead.

Key terms

Contrast agent — A substance that makes shadows on x rays.
Filariasis — A tropical disease caused by worms that live in lymph channels.
Hodgkin's disease — A cancer of the lymphatic system.
Lymphoma — A type of lyphatic cancer.


Prior to suture removal seven to 10 days after the procedure, the patient should watch for any sign of infection around the site.


Lipid pneumonia can occur if the contrast agent penetrates the thoracic duct. An allergic reaction to the contrast agent is possible, causing a range of symptoms that can range from innocuous to life threatening.



Merrill, Vinta. "Lymphangiography." In Atlas of Roentgenographic Positions and Standard Radiologic Procedures. Saint Louis: The C. V. Mosby Co., 1975.


angiography of lymphatic channels.


Radiographic demonstration of lymphatics and lymph nodes following the injection of a contrast medium; lymphography.
[lymphangio- + G. graphō, to write]


/lym·phan·gi·og·ra·phy/ (lim-fan″je-og´rah-fe) angiography of lymphatic vessels.


n. pl. lymphangiogra·phies
Examination of the lymph nodes and lymphatic vessels following the injection of a radiopaque substance. Also called lymphography.

lym·phan′gi·o·gram′ (-ə-grăm′) n.


an x-ray done with contrast dye that is especially useful in patients suspected of having lymphoma, metastatic tumor, or Hodgkin's disease. It is also used to demonstrate the extent and level of lymphatic metastasis, to stage lymphoma patients, to evaluate the results of chemotherapy or radiation therapy, and to evaluate patients with chronic leg swelling.


 Imaging A radiologic exam of the lymphatic circulation by injecting radiocontrast or dye at the feet, to examine the legs, inguinal and iliac regions and retroperitoneum as high as the thoracic duct–or the hands, to visualize axillary and supraclavicular lymphatic circulation and lymph nodes


Radiographic demonstration of lymphatics and lymph nodes following the injection of a contrast medium; lymphography; obsolete procedure.
[lymphangio- + G. graphō, to write]


radiography of lymphatic channels after introduction of a contrast medium.
References in periodicals archive ?
Staging MR lymphangiography of the axilla for early breast cancer: cost-effectiveness analysis.
In many instances, CT scans may effectively be used in place of lymphangiography.
Accurate staging depends on the findings of the laparotomy, lymphangiography, IVP, barium enema, and other diagnostic procedures.
Various radiologic examinations also are used, including lymphoscintigraphy, lymphangiography, magnetic resonance imaging, computed tomography and sodium-24 studies.
Although lymphangiography is still the method that most completely reveals lymphatic anatomy, it offers little information about lymphatic function and it has complications.
Lymphoscintigraphy offers an effective, relatively simple procedure compared to conventional lymphangiography.
In a 1992 study, Case et al[26] provided scintigraphic and MR comparison images and concluded that MR was a valuable complement to lymphoscintigraphy for diagnosis of lymphedema; they believe that use of the two imaging systems together could be as accurate as lymphangiography without the complications.
Techniques used to determine the extent of dissemination of prostate cancer and histological differentiation include sonography, computed tomography, magnetic resonance imaging, radionuclide bone scans and lymphangiography.
Bipedal lymphangiography is the most extensively investigated nonsurgical means of evaluating the pelvic lymph nodes for the spread of prostate cancer.
Lymph nodes represent the primary drainage site of the prostate, and there is controversy whether they are consistently filled and visualized during lymphangiography.