lymphadenopathy


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.

lymphadenopathy

 [lim-fad″ĕ-nop´ah-the]
disease of the lymph nodes; called also adenopathy.
angioimmunoblastic lymphadenopathy (angioimmunoblastic lymphadenopathy with dysproteinemia (AILD)) a systemic disorder resembling lymphoma characterized by fever, night sweats, weight loss, generalized lymphadenopathy, hepatosplenomegaly, macropapular rash, polyclonal hypergammaglobulinemia, and Coombs'-positive hemolytic anemia. It is considered to be a nonmalignant hyperimmune reaction to chronic antigenic stimulation; there is proliferation of B cells accompanied by profound deficiency of T cells. The disease follows a progressive but extremely variable course: some patients survive for a long period without chemotherapy; in other patients, overwhelming infections rapidly lead to death
dermatopathic lymphadenopathy regional lymph node enlargement associated with melanoderma and other dermatoses marked by chronic erythroderma.
immunoblastic lymphadenopathy angioimmunoblastic lymphadenopathy.
lymphadenopathy syndrome a condition occurring in immunocompromised individuals, characterized by unexplained lymphadenopathy for 3 or more months that involves extrainguinal sites, which on biopsy reveal nonspecific lymphoid hyperplasia. See also AIDS-related complex.

lym·phad·e·nop·a·thy

(lim-fad'ĕ-nop'ă-thē),
1. Any disease process affecting a lymph node or lymph nodes.
2. The appearance of enlarged lymph nodes found on a radiologic examination of any kind.
[lymphadeno- + G. pathos, suffering]

lymphadenopathy

(lĭm-făd′n-ŏp′ə-thē, lĭm′fə-dn-)
n. pl. lymphadenopa·thies
An enlargement of the lymph nodes, usually associated with disease.

lymphadenopathy

A generic term for lymph node enlargement of any aetiology, benign or malignant.

Lymphadenopathy, aetiology
Infection
• Viral—Infectious mononucleosis, CMV, HIV.
• Bacterial—Typhoid, TB, syphilis, Yersinia.
Malignancy
• Lymphoproliferative—especially lymphoma
• Metastases.

Storage
Lipid storage, Niemann-Pick, sphingomyelia.

Drugs
Phenytoin, allopurinol, isoniazid.

Immune
Automimmune, rheumatoid arthritis, sarcoid, GVHD.

Benign hyperplasia, Langerhans cell histiocytosis.

lymphadenopathy

Enlarged lymph nodes, follicular hypertrophy, swollen lymph glands Hematology Enlargement of lymph nodes of any etiology; the differential diagnostic considerations are multiple and divided into reactive patterns; benign lymphadenopathy is characterized by
1. Variability of the follicle–germinal center size;.
2. Lack of capsular or fat invasion;.
3. Mitotic activity confined to the germinal center;.
4. Cortical localization and inhomogeneous distribution of the follicles. See Angiography lymphadenopathy, Benign lymphadenopathy, Dermatopathic lymphadenopathy, Phenytoin lymphadenopathy, Shotty lymphadenopathy.

lym·phad·e·nop·a·thy

(lim-fad'ĕ-nop'ă-thē)
Any disease process affecting a lymph node or lymph nodes.
[G. lympha spring water +aden gland + G. pathos, suffering]

lymphadenopathy

(lim″fad″ĕ-nop′ă-thē) [ lymph- + adenopathy]
Enlarge picture
CERVICAL LYMPHADENOPATHY: Squamous cell carcinoma of the neck
Enlargement of lymph nodes (LN), typically to greater than 1.5 cm. The increased size is caused by activation and proliferation of lymphocytes and phagocytic white blood cells within the node or by invasion of the node by tumor. Most often, lymphadenopathy is found in nodes involved in local, regional, or systemic infections; it results occasionally from cancers. Lymphadenopathy may also be found in an array of other, less common illnesses, including thyroiditis, thyrotoxicosis, autoimmune diseases (e.g., rheumatoid arthritis), sarcoidosis, and drug reactions (e.g., phenytoin). See: illustration

Enlarged LNs may be tender or not; tenderness often is present when lymph nodes swell rapidly (e.g., in response to infections, hypersensitivity reactions, or some fulminant lymphomas). Rock-hard, enlarged, and immobile LNs are typical of metastatic cancer, whereas rubbery LNs are found in lymphomas. LNs that do not resolve spontaneously within 4 to 6 weeks, or for which no obvious explanation exists, usually are sampled by biopsy or aspiration.

dermatopathic lymphadenopathy

Widespread lymphadenopathy secondary to various skin disorders.
See: table
CategoryExamplesLocationAge of patientTextureSizeAssociated signs or symptomsDiagnostic testsNecessity for biopsy or aspirate
Bacterial infectionStrep throat; cat scratch diseaseAngle of the jaw; axilla, neckChild or preteen; anyRelatively soft and tender; relatively soft and tender1 sq. cm; > 1 cmFever, sore throat, tonsillar exudate, malaise, headache, difficulty swallowing; may have fever, night sweats, weight lossCan be diagnosed clinically; antibody blood testsNo; not usually
GranulomaTuberculosis; sarcoidosisNeck, chest; hilum of the lung and other locationsAny; usually adultsRelatively soft and tender; rubbery> 1 cm; > 1 cm, sometimes massiveMay have fever, night sweats, weight loss, productive sputum; cough, shortness of breath, may have systemic illness, or be asymptomaticTuberculin (purified protein derivative), interferon blood test, sputum for acid-fast bacilli; blood for ACE levelsOccasionally; often
Metastatic cancerBreast cancerAxilla next to the breastAdultsStoneEspecially likely if > 2 cmLump in the breastMammography, ultrasound, other imaging techniquesYes
LymphomaHodgkin lymphomaChest, neck, axilla, groin, or all of these Young adultRubbery> 1 cmMay have fever, night sweats, weight loss, enlarged spleenRadiologic imagingYes
Viral infectionMononucleosis; HIV/AIDSHead and neck, spleen; generalizedYoung adult; any, but most often young adult or adultRubbery; firmAbout 1 cm; variableMay have fever, night sweats, weight loss; fever, night sweats, weight loss, or symptoms of opportunistic infectionTests for Epstein-Barr virus, heterophile antibody; antibody blood testsNo; not usually

lymphadenopathy

Any disease process affecting a LYMPH NODE. Also known as lymphadenosis.

lymphadenopathy

An enlargement of a lymph gland. The preauricular lymph node located 1 cm in front of the external ear drains the orbital region and is sometimes involved with eyelid and conjunctival infection (e.g. adult inclusion conjunctivitis, follicular conjunctivitis). Syn. adenopathy (although strictly speaking this term refers to the enlargement of any gland).

lym·phad·e·nop·a·thy

(lim-fad'ĕ-nop'ă-thē)
1. Any disease process affecting lymph nodes.
2. The appearance of enlarged lymph nodes found on x-rays.
[G. lympha spring water + aden gland + G. pathos, suffering]

Patient discussion about lymphadenopathy

Q. my friend ate a bar of chocolate and now her left neck gland is swollen any ideas why? no other symptoms

A. it can be an infection -just like brandon said- or although this is rare, it can also be an allergic reaction.
if it is an infection, you can usually find such other infection symptoms like : fever, pain in that swollen area, increased white blood cells (in blood work test), etc.

if it is an allergy, usually it will fade away itself in couple of days, or you can just try to consume anti-allergic drugs, such as : loratadine and maybe combined with dexamethasone.

Good luck, and stay healthy always..

More discussions about lymphadenopathy
References in periodicals archive ?
Rosai-Dorfman Disease is a rare benign disorder which clinically presents with bilateral cervical lymphadenopathy. Extra-nodal manifestation is common but gastrointestinal system involvement is rare.
The current study conducted at a tertiary care hospital in Rajasthan included 250 cases where FNA was performed on cervical lymphadenopathy. There was male predominance of cases in this study with male to female ratio being 2.6:1.
Diagnostic aspects of cervical lymphadenopathy in children in the developing world: a study of 1,877 surgical specimens.
y/sex Fever lymphadenopathy with animal 1 15/M + + Cat, dog 2 4/F + - Cat 3 6/F + - Dog 4 13/M + + Cat 5 14/F + + Cat, dog 6 8/M + + Dog 7 10/M + + Cat 8 8/F + + Dog 9 10/M + + Cat 10 7/F + + Cat 11 2/M + + Cat 12 15/M + - Cat, dog 13 6/F + + Cat 14 10/M + + Cat 15 12/F + + Cat, dog 16 13/M + - Cat 17 9/F + + Cat 18 4/M + + Cat 19 14/F + - Dog, rabbit 20 56/F + - Cat 21 35/F + + Cat 22 7/M + + Cat, dog IFA titer Patient Patient age, Cp of rPCR, no.
Cervical lymphadenopathy is usually defined as cervical lymph node measuring more than 1cm in diameter.
The last patient had a remote serous fallopian carcinoma and FIGO IIIC and subsequently developed mediastinal lymphadenopathy found on CT.
Dorfman, "Sinus histiocytosis with massive lymphadenopathy: a pseudolymphomatous benign disorder.
de la Cruz et al., "Tick-borne tularemia: an outbreak of lymphadenopathy in children," JAMA, vol.
His extensive lymphadenopathy adds to the extremely rare cases reported in the literature of hilar, para-tracheal lymphadenopathy, axillary, and retroperitoneal lymphadenopathy.
(2) Axillary dissection for a known breast cancer with axillary lymphadenopathy
USG-guided fine-needle aspiration(FNA) taken from the mesenteric lymph nodes showed lymphocyte predominance, few centro blasts,and centrocytes in the background of lympho glandular bodies and red blood cells without granuloma and epitheloid cells; which is suggestive of reactive lymphadenopathy.
In 1972, Rosai and Dorfman [2] performed clinicopathological analyses on 34 patients and named this disease sinus histiocytosis with massive lymphadenopathy (SHML), which is characterized by painless lymphadenopathy, fever, patches of massive proliferation of histiocytes, and the presence of engulfed lymphocytes in the cytoplasm of these histiocytes.