lyase


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Related to lyase: Ligases, Isomerases

lyase

 [li´ās]
any of a class of enzymes that remove groups from their substrates (other than by hydrolysis), leaving double bonds, or that conversely add groups to double bonds.

ly·ase

(lī'ās),
Class name for those enzymes removing groups nonhydrolytically (EC class 4); prefixes such as "hydro-" and "ammonia-" are used to indicate the type of reaction. Trivial names for lyases include synthases, decarboxylases, aldolases, and dehydratases. Compare: synthase, synthetase.

lyase

/ly·ase/ (li´ās) any of a class of enzymes that remove groups from their substrates (other than by hydrolysis or oxidation), leaving double bonds, or that conversely add groups to double bonds.

lyase

(lī′ās′)
n.
Any of a group of enzymes that catalyze the cleavage of bonds without hydrolysis or oxidation, often resulting in a new double bond or ring structure, or that catalyze the addition of chemical groups to double bonds.

ly·ase

(lī'ās)
Class name for enzymes removing groups nonhydrolytically (EC class 4); prefixes such as "hydro-," and "ammonia-" are used to indicate the type of reaction. Trivial names for lyases include synthases, decarboxylases, aldolases, dehydratases.
Compare: synthase, synthetase

lyase

an enzyme that catalyses
  1. the addition of groups to double bonds,
  2. the removal of groups to form double bonds.

lyase

any of a class of enzymes that remove groups from their substrates (other than by hydrolysis), leaving double bonds, or that conversely add groups to double bonds.
References in periodicals archive ?
McKinney, Jacobs, and their colleagues are taking another tack toward new TB treatments, using the crystal structure of isocitrate lyase as a blueprint.
Biochemical basis of resistance was determined by quantification of total phenolics and defense related enzymes including peroxidase (PO) Polyphenoloxidase (PO) and Phenyl ammonia lyase (PAL).
Another autosomal recessive inborn error of metabolism is 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) lyase deficiency (HMGCLD; OMIM 246450).
Both DMSP and DMSP lyase reside within algal cells, but the chemical reaction doesn't take place unless a cell is injured--by a hungry predator, for example.
a biopharmaceutical company focused on developing new treatments for prostate cancer, today announced that new preclinical data demonstrating the differentiated potent and selective CYP17 lyase inhibition mechanism of action of its lead candidate, galeterone (TOK-001), will be presented today in a poster presentation titled, "Galeterone, Abiraterone, Orteronel and Ketoconazole Exhibit Differential Inhibitory Effects on CYP17 and Steroidogenesis," abstract number 184, at the 2013 American Society of Clinical Oncology Genitourinary Cancers Symposium (ASCO GU) in Orlando, Fla.
The most advanced of these molecules are VT-464, an orally-active small molecule inhibitor of the enzyme CYP17 lyase, which is in phase 1/2 clinical development for the treatment of castration-refractory prostate cancer, and VT-1161, an orally-active small molecule inhibitor of the fungal enzyme CYP51, which recently completed phase 1 clinical testing with a target indication of onychomycosis.
Differential Induction of Phenylalanine Ammonia Lyase in date palm roots in response to inoculation with Fusarium oxysporum f.
Bugg says the researchers have harvested plenty of new data from the remaining three: porcine pancreatic elastase (a pig enzyme similar to one that damages lung tissue in leukemia patients); isocitrate lyase (an enzyme in nematodes); and gamma interferon (a protein that stimulates the immune system).
Orteronel, an oral, non-steroidal androgen synthesis inhibitor was discovered by Takeda and has so far shown in pre-clinical studies that it selectively inhibits the 17, 20 lyase enzymes 1 which are central to the production of steroidal androgens in the testes and adrenal glands.
Galeterone is unique in that it is the first and only single agent therapeutic that combines three distinct approaches to attack prostate cancer, acting as a selective CYP17 lyase inhibitor, an androgen receptor antagonist and by decreasing overall androgen receptor levels in prostate cancer tumors cells in preclinical studies," said Philip Kantoff, M.
In preclinical models VT-464 preferentially inhibits the lyase reaction of the CYP17 enzyme over the hydroxylase reaction, which differentiates it from approved agents such as abiraterone acetate.