lyase


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Related to lyase: Ligases, Isomerases

lyase

 [li´ās]
any of a class of enzymes that remove groups from their substrates (other than by hydrolysis), leaving double bonds, or that conversely add groups to double bonds.

ly·ase

(lī'ās),
Class name for those enzymes removing groups nonhydrolytically (EC class 4); prefixes such as "hydro-" and "ammonia-" are used to indicate the type of reaction. Trivial names for lyases include synthases, decarboxylases, aldolases, and dehydratases. Compare: synthase, synthetase.

lyase

(lī′ās′)
n.
Any of a group of enzymes that catalyze the cleavage of bonds without hydrolysis or oxidation, often resulting in a new double bond or ring structure, or that catalyze the addition of chemical groups to double bonds.

ly·ase

(lī'ās)
Class name for enzymes removing groups nonhydrolytically (EC class 4); prefixes such as "hydro-," and "ammonia-" are used to indicate the type of reaction. Trivial names for lyases include synthases, decarboxylases, aldolases, dehydratases.
Compare: synthase, synthetase

lyase

an enzyme that catalyses
  1. the addition of groups to double bonds,
  2. the removal of groups to form double bonds.
References in periodicals archive ?
3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) lyase deficiency is usually clinically evident during infancy and is characterized by vomiting, hypotonia, lethargy, metabolic acidosis, non-ketotic hypoglycemia, and Reyelike syndrome.
A proper enological extraction enzyme should have a high PG (enzyme polygalaturonase) to PL (enzyme pectin lyase) ratio and be low in side activities of cellulase and hemi-cellulase which can release unwanted seed tannins.
carotovorum and other soft rot species to macerate plant tissue is dependent on their massive production and secretion of plant cell wall-degrading enzymes, especially pectinolytic enzymes such as polygalacturonase (Peh), pectin lyase (Pnl) and isoforms of pectate lyase (Pel) [25].
We applied dbCAN [30] with default parameters and identified a total of 301 CAZyme-coding gene homologs (Appendix S4), which includes 127 glycoside hydrolases (GH), 64 glycosyltransferases (GT), 55 carbohydrate esterases (CE), 30 with auxiliary activities (AA), 19 carbohydrate binding module (CBM), and 6 polysaccharide lyases (PL).
demonstrate that the use of a structural analogue of S1P (FTY720) attenuates lung injury induced by ischemia- reperfusion by modulating S1P lyase (S1PL), sphingosine kinase 1 (SphKl), and SphK2.
Garcinia cambogia contains the active ingredient hydroxycitric acid, which is thought to inhibit the body's production of lipids via an enzyme called citrate lyase.
UV-C irradiation has upregulated phenylalanine-ammonia lyase (PAL) and induced the accumulation of phenolic compounds in some [13,16,17] but not in all cases [18].
One of them, the Fpg (MutM) DNA glycosylase-AP lyase, removes the oxidized base from G:C base pairs in duplex DNA.
Congenital adrenal hyperplasia owing to 17alpha-hydroxylase/17,20 lyase and p450 oxido-reductase deficiencies.
The results indicated that the key enzymes included in namely phenylalanine ammonia lyase, flavonoid biosynthesis, chalcone isomerase and chalcone synthase activities were markedly increased by GNT treatment.
In the presence of the 17a-hydroxylase but not the 17, 20 lyase activity of P450c17 in the fasciculate zone, C21, 17-hydroxy-steroids are produced, leading to the glucocorticoid production (Miller, 2009).
Isocitrate lyase (EC 4.1.3.1) and malate synthase (EC 2.3.3.9) are the sole enzymes for this metabolic pathway.