McKinney, Jacobs, and their colleagues are taking another tack toward new TB treatments, using the crystal structure of isocitrate lyase
as a blueprint.
Bacillus cereus GS-2 isolated from fruit industrial dump site effectively produces pectin lyase
(PL) and Polygalacturonase (PG).
Biochemical basis of resistance was determined by quantification of total phenolics and defense related enzymes including peroxidase (PO) Polyphenoloxidase (PO) and Phenyl ammonia lyase
Another autosomal recessive inborn error of metabolism is 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) lyase
deficiency (HMGCLD; OMIM 246450).
Both DMSP and DMSP lyase
reside within algal cells, but the chemical reaction doesn't take place unless a cell is injured--by a hungry predator, for example.
a biopharmaceutical company focused on developing new treatments for prostate cancer, today announced that new preclinical data demonstrating the differentiated potent and selective CYP17 lyase
inhibition mechanism of action of its lead candidate, galeterone (TOK-001), will be presented today in a poster presentation titled, "Galeterone, Abiraterone, Orteronel and Ketoconazole Exhibit Differential Inhibitory Effects on CYP17 and Steroidogenesis," abstract number 184, at the 2013 American Society of Clinical Oncology Genitourinary Cancers Symposium (ASCO GU) in Orlando, Fla.
The most advanced of these molecules are VT-464, an orally-active small molecule inhibitor of the enzyme CYP17 lyase
, which is in phase 1/2 clinical development for the treatment of castration-refractory prostate cancer, and VT-1161, an orally-active small molecule inhibitor of the fungal enzyme CYP51, which recently completed phase 1 clinical testing with a target indication of onychomycosis.
Differential Induction of Phenylalanine Ammonia Lyase
in date palm roots in response to inoculation with Fusarium oxysporum f.
Bugg says the researchers have harvested plenty of new data from the remaining three: porcine pancreatic elastase (a pig enzyme similar to one that damages lung tissue in leukemia patients); isocitrate lyase
(an enzyme in nematodes); and gamma interferon (a protein that stimulates the immune system).
Orteronel, an oral, non-steroidal androgen synthesis inhibitor was discovered by Takeda and has so far shown in pre-clinical studies that it selectively inhibits the 17, 20 lyase
enzymes 1 which are central to the production of steroidal androgens in the testes and adrenal glands.
Galeterone is unique in that it is the first and only single agent therapeutic that combines three distinct approaches to attack prostate cancer, acting as a selective CYP17 lyase
inhibitor, an androgen receptor antagonist and by decreasing overall androgen receptor levels in prostate cancer tumors cells in preclinical studies," said Philip Kantoff, M.
In preclinical models VT-464 preferentially inhibits the lyase
reaction of the CYP17 enzyme over the hydroxylase reaction, which differentiates it from approved agents such as abiraterone acetate.