LHCGR

(redirected from lutropin-choriogonadotropic hormone receptor)

LHCGR

A gene on chromosome 2p21 that encodes a cell surface receptor for both luteinising hormone and choriogonadotropin, which belongs to the G-protein-coupled receptor 1 family. LHCGR’s activity is mediated by adenylate cyclase-activating G proteins.

Molecular pathology
LHCGR mutations cause a range of disorders affecting male secondary sexual development, such as familial male precocious puberty (testotoxicosis), hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty and male pseudohermaphtoditism with Leydig cell hypoplasia.
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References in periodicals archive ?
By two GO enrichment analyses, one interesting phenomenon is observed; that is, XYP may have similar effects of procreation endocrine regulation to western medicines by target clinically used therapeutic targets such as estrogen receptor alpha (ESR1), estrogen receptor beta (ESR2), progesterone receptor (PGR), insulin receptor (INSR), androgen receptor (AR) follicle-stimulating hormone receptor (FSHR), and lutropin-choriogonadotropic hormone receptor (LHCGR).