These phases correspond to the period of luteolysis
and follicular development, which, in turn, causes decline of progesterone and increase of estrogen.
It is not possible to conclude if the results are a consequence of decreased discomfort or due to luteolysis
inhibition by the anti-inflammatory.
This short-term feeding stage is a critical period in the luteal phase of the estrous cycle (Somchit et al., 2007) or during the 6-day period before functional luteolysis
(King et al., 2010).
This enzyme also belongs to the family of oxidoreductases, and it has shown to play a significant role in luteolysis
(25) Also, folate has antioxidant properties that counteract reactive oxygen species (ROS) which affect oocyte maturation, ovulation, luteolysis
, and follicle atresia.
Although GnRH trigger is currently regarded as the best tool for OHSS prevention, intensive luteal support with exogenous administration of estradiol and progesterone or low-dose hCG on the day of oocyte retrieval or on the day of GnRH agonist trigger are required to achieve optimal conception rates due to early luteolysis
. Among currently available dopamine agonists, cabergoline, quinagolide and bromocriptine are the most common drugs that should be used for prevention of both early and late OHSS.
It is important to consider that the marker used to identify macrophages reveals specific information about the changing functional characteristics of the cells; for instance, in the rabbit, luteolysis
was associated with an initial increase in scavenger receptor positive macrophages followed by recruitment of CD68 positive macrophages (Song et al.).
The remaining granulosa and theca cells differentiate into the corpus luteum, which produces progesterone for pregnancy maintenance, or alternatively undergoes luteolysis
Colin Duncan, "Regulated C-C motif ligand 2 (CCL2) in luteal cells contributes to macrophage infiltration into the human corpus luteum during luteolysis
," Molecular Human Reproduction, vol.
However, the outcome in case of failure of the corpus luteum to undergo luteolysis
may be prolonged gestation, pyometra, or fetal mummification [18, 19].