SERCA inactivation by nitration may lead to the reduced function of the ion pump, hence compromising lusitropy
as an early event in the development of CHF .
Levosimendan is a calcium sensitizer that enhances cardiac contractility without increasing oxygen consumption by increasing calcium sensitivity of cardiomyocyte contractile apparatus during systole, without increasing intracellular calcium concentration, resulting in the acceleration of actin-myosin cross bridge formation rate without prolonging relaxation time (positive lusitropy
Impact of restrictive physiology on intrinsic diastolic right ventricular function and lusitropy
in children and adolescents after repair of tetralogy of Fallot.
Traditionally, understanding of cardiovascular physiology starts with widely used but non-quantitative cardiocentric concepts such as inotropy and lusitropy
, the relaxation properties of the heart in diastole.
The concentration-dependent increase in the amplitude (i.e., positive inotropy) and decrease in the relaxation time (i.e., positive lusitropy) of CS induced by [TA.sub.AqE] were summarized in the left and right panels of Fig.
Taken together, these results suggest that [TA.sub.AqE] increases SR available [Ca.sup.2+] content in AVM, consistent with its increase in SR [Ca.sup.2+] uptake and its positive lusitropy.
In athlete's heart, this is reflected in better inotropy, lusitropy
, and augmented cardiac pumping capacity (Katz and Lorell, 2000), which are clearly an advantage.
Internists, family physicians, and even cardiologists who aren't echocardiographers find baffling the terms we routinely use to describe diastolic dysfunction: impaired relaxation, restrictive filling, lusitropy
, and here's one that really messes people up--pseudonormalization.
Influence of altered inotropy and lusitropy
on ventricular pressure-volume loops.