ROS mediated cardiac depression also leads to decline in the inotropic (+LVdP/dt) and lusitropic
(-LVdP/dt) states of the heart.
Whereas, dP/dt(min) and diastolic pressure remained unaffected; indicating no lusitropic
The Frank--Starling Law shows that the increase in the ventricular filling streches the ventricle walls, which contract even stronger to eject blood volume; there is a positive inotropic and lusitropic
effect when the end-diastolic pressure volume increases.
In vitro experiments suggested positive inotropic and lusitropic
properties of HNO, while subsequent studies in healthy and heart failure dog models with the HNO donor Angeli's salt ([Na.
Abstract: Pimobendan is a phosphodiesterase (PDE) inhibitor and calcium sensitizer with inotropic, lusitropic
, and rasodilator properties used in the treatment of congestive heart failure.
Effects of istaroxime on diastolic stiffness in acute heart failure syndromes: results from the Hemodynamic, Echocardiographic, and Neurohormonal Effects of Istaroxime, a Novel Intravenous Inotropic and Lusitropic
Agent: a Randomized Controlled Trial in Patients Hospitalized with Heart Failure (HORIZON-HF) trial.
A positive lusitropic
effect of NO has previously been reported in contracting papillary muscle strips, isolated ejecting guinea-pig heart and following intracoronary infusions in humans (22-24).
The two gases were found to interact together to form a thiol-sensitive compound (linked to the sulphur in H2S) which produces inotropic (muscular contraction) and lusitropic
(muscular relaxation) effects in the heart.
Analysis of lusitropic
indices (A, E, or E/A) indicated that the E/A ratio was higher in BP as compared with that of strength/power athletes (p < 0.
In preclinical studies using models of hypertension and heart failure, Vasomera(TM)demonstrated prolonged and significant dose dependent reductions in mean arterial pressure as well as positive inotropic and lusitropic
effects without increasing myocardial oxygen consumption.
About this, the cardiovascular effect of flavonoids is not new; for example, the activity of Quercetin and Myricetin has distinct signaling mechanism; Quercetin induced biphasic inotropic and lusitropic
effect, positive at lower concentrations and negative at higher concentrations, while Myricetin elicits coronary dilation without affecting contractility and relaxation .
However, the lusitropic
response to b adrenergic agents was abnormal regardless of restrictive physiology.