The mechanical behavior of the papillary muscle was evaluated under baseline conditions at 2.5 mM [Ca.sup.2+] and after inotropic and lusitropic
maneuvers: length-tension relationship, increases in extracellular [Ca.sup.2+] concentrations (to test their effects on myofilament machinery), and post-rest contraction (PRC), mainly related to SR storage and release capacity.
Persehaye, "The inotropic and lusitropic
effects of ketamine in isolated human atrial myocardium: the effect of adrenoceptor blockade," Analgesia, pp.
Usually, catecholamines bind to beta1 and beta2-adrenergic receptors and produce positive inotropic and lusitropic
Kersten et al., "Direct negative inotropic and lusitropic
effects of sevoflurane," Anesthesiology, vol.
In the present study, the IR group exhibited significant impairment of systolic and diastolic function, depicted by a decrease in MAP, as well as by impaired inotropic and lusitropic
state, represented by a fall in +LVdP/dtmax and -LVdP/dtmax, respectively, along with increased LVEDP which characterizes increased preload on the compromised heart.
have revealed that glycyrrhizin has positive inotropic and lusitropic
effects which were negatively affected by glycyrrhetinic acid.
ROS mediated cardiac depression also leads to decline in the inotropic (+LVdP/dt) and lusitropic
(-LVdP/dt) states of the heart.
Whereas, dP/dt(min) and diastolic pressure remained unaffected; indicating no lusitropic
The Frank--Starling Law shows that the increase in the ventricular filling streches the ventricle walls, which contract even stronger to eject blood volume; there is a positive inotropic and lusitropic
effect when the end-diastolic pressure volume increases.
Abstract: Pimobendan is a phosphodiesterase (PDE) inhibitor and calcium sensitizer with inotropic, lusitropic
, and rasodilator properties used in the treatment of congestive heart failure.
Effects of istaroxime on diastolic stiffness in acute heart failure syndromes: results from the Hemodynamic, Echocardiographic, and Neurohormonal Effects of Istaroxime, a Novel Intravenous Inotropic and Lusitropic
Agent: a Randomized Controlled Trial in Patients Hospitalized with Heart Failure (HORIZON-HF) trial.
A positive lusitropic
effect of NO has previously been reported in contracting papillary muscle strips, isolated ejecting guinea-pig heart and following intracoronary infusions in humans (22-24).