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lu·pus an·ti·co·ag·u·lant (LA),
antiphospholipid antibody causing elevation in partial thromboplastin time; associated with venous and arterial thrombosis.
an antibody specific for phospho-lipoproteins or phospholipid components of coagulation factors, found in patients with systemic lupus erythematosus. It causes an increase in partial thromboplastin time and is associated with arterial and venous thrombosis, fetal loss, and thrombocytopenia.
lupus anticoagulantLupus inhibitor Lab Medicine Any IgG or IgM class antibody that arise spontaneously in Pts with SLE; while LAs produce in vitro interference with phospholipid-dependent coagulation–eg, activated partial thromboplastin time–aPTT and kaolin clotting time assays in specimens from Pts with LE, they do not produce in vivo coagulopathy without other platelet or coagulation defects or drug-induced antibodies; LAs also occur in Pts with HIV, DVT, and other conditions Lab ↑ aPTT; LAs interfere with derivative assays for factors VIII, IX, XI, and XII. See Systemic lupus erythematosus. Cf Anticardiolipin antibodies.
lu·pus an·ti·co·ag·u·lant(lū'pŭs an'tē-kō-ag'yŭ-lănt)
Antiphospholipid antibody causing elevation in partial thromboplastin time; associated with venous and arterial thrombosis.