lupus anticoagulant


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lu·pus an·ti·co·ag·u·lant (LA),

antiphospholipid antibody causing elevation in partial thromboplastin time; associated with venous and arterial thrombosis.

lupus anticoagulant

Lupus inhibitor Lab Medicine Any IgG or IgM class antibody that arise spontaneously in Pts with SLE; while LAs produce in vitro interference with phospholipid-dependent coagulation–eg, activated partial thromboplastin time–aPTT and kaolin clotting time assays in specimens from Pts with LE, they do not produce in vivo coagulopathy without other platelet or coagulation defects or drug-induced antibodies; LAs also occur in Pts with HIV, DVT, and other conditions Lab ↑ aPTT; LAs interfere with derivative assays for factors VIII, IX, XI, and XII. See Systemic lupus erythematosus. Cf Anticardiolipin antibodies.

lu·pus an·ti·co·ag·u·lant

(lū'pŭs an'tē-kō-ag'yŭ-lănt)
Antiphospholipid antibody causing elevation in partial thromboplastin time; associated with venous and arterial thrombosis.

lupus anticoagulant

An antibody, or groups of antibodies, to negatively-charged phospholipids liable to be associated, paradoxically, with a tendency for blood to clot within the blood vessels. This may lead to deep vein thrombosis, arterial thrombosis with strokes and heart attacks and, in pregnant women, a strong tendency to fetal death and abortion. Some patients with LUPUS ERYTHEMATOSUS are known to have a positive result in tests for syphilis while not suffering from the disease. This effect is caused by the lupus anticoagulant. See also HUGHES' SYNDROME.
References in periodicals archive ?
As measurement using the fluorescent microbeads method is almost completely unaffected by the presence or absence of residual FVIII:C, use of the method allows for detection of antibodies without the undue influence of the presence of lupus anticoagulants or heparin.
This patient had a complicated presentation and history with prolonged malaria, schistosomes, drug treatment, haemolytic anaemia, thrombocytopenia and lupus anticoagulant. Potential causes and relationships between these features are discussed below.
* The lupus anticoagulant (screening and confirmation) was tested via the chronometric method on the compact STA analyzer using the following reagents from Diagnostica Stago Laboratories: STA STACLOT DRVV screen and STA STACLOT DRVV confirm.
No correlation was found between PTS and the presence of coagulation abnormalities (deficiency of protein C, protein S, and antithrombin; factor V Leiden; lupus anticoagulant and hyperhomocysteinemia, all together present in 51% of patients).
Lupus anticoagulants cause a prolongation of the aPTT, probably as a result of hypoprothrombinemia induced by antiprothrombin antibodies.
"Lupus anticoagulant is the most important predictor of risk and high titer anticardiolipin antibodies alone don't provide substantial risk," said Dr.
The fact that lupus anticoagulant is a strong risk factor for thrombosis in SLE (17) suggests the possibility of a future thrombotic event such as myocardial ischaemia in our patient, since she was positive on lupus anticoagulant testing.
Although our patient had positive aPL (lupus anticoagulant and high titre IgM anticardiolipin antibodies) and a thrombotic event, the aPL were only tested on one occasion and the pulmonary emboli occurred post-operatively.
A repeat lupus anticoagulant at 6 weeks remained negative.
A rheumatologist was also consulted and further blood tests, including anti--double-stranded DNA and antiphospholipid antibodies (anticardiolipid antibody and lupus anticoagulant) for suspected SLE were suggested.