lupus anticoagulant


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.

lu·pus an·ti·co·ag·u·lant (LA),

antiphospholipid antibody causing elevation in partial thromboplastin time; associated with venous and arterial thrombosis.

lupus anticoagulant

an antibody specific for phospho-lipoproteins or phospholipid components of coagulation factors, found in patients with systemic lupus erythematosus. It causes an increase in partial thromboplastin time and is associated with arterial and venous thrombosis, fetal loss, and thrombocytopenia.

lupus anticoagulant

Lupus inhibitor Lab Medicine Any IgG or IgM class antibody that arise spontaneously in Pts with SLE; while LAs produce in vitro interference with phospholipid-dependent coagulation–eg, activated partial thromboplastin time–aPTT and kaolin clotting time assays in specimens from Pts with LE, they do not produce in vivo coagulopathy without other platelet or coagulation defects or drug-induced antibodies; LAs also occur in Pts with HIV, DVT, and other conditions Lab ↑ aPTT; LAs interfere with derivative assays for factors VIII, IX, XI, and XII. See Systemic lupus erythematosus. Cf Anticardiolipin antibodies.

lu·pus an·ti·co·ag·u·lant

(lū'pŭs an'tē-kō-ag'yŭ-lănt)
Antiphospholipid antibody causing elevation in partial thromboplastin time; associated with venous and arterial thrombosis.

lupus anticoagulant

An antibody, or groups of antibodies, to negatively-charged phospholipids liable to be associated, paradoxically, with a tendency for blood to clot within the blood vessels. This may lead to deep vein thrombosis, arterial thrombosis with strokes and heart attacks and, in pregnant women, a strong tendency to fetal death and abortion. Some patients with LUPUS ERYTHEMATOSUS are known to have a positive result in tests for syphilis while not suffering from the disease. This effect is caused by the lupus anticoagulant. See also HUGHES' SYNDROME.
References in periodicals archive ?
Coagulation testing suggests our patient developed lupus anticoagulant but she had no clinical features of APS.
The lupus anticoagulant is a risk factor for myocardial infarction (but not atherosclerosis): Hopkins Lupus Cohort.
The presence of lupus anticoagulant was confirmed in 2 patients (Table 2).
Clinical significance of lupus anticoagulants in children.
The fact that lupus anticoagulant is a strong risk factor for thrombosis in SLE (17) suggests the possibility of a future thrombotic event such as myocardial ischaemia in our patient, since she was positive on lupus anticoagulant testing.
This is the case report of a 23 year-old female with an antiphospholipid syndrome, characterized by recurrent deep venous thrombosis and fetal losses, showing positive lupus anticoagulant and anticardiolipin antibodies.
Following is a review of the most likely risk factors, including antiphospholipid antibody syndrome (APS), previously known as lupus anticoagulant syndrome; heparin-induced thrombocytopenia (HIT); pregnancy; trauma; estrogen; and malignancy.
In addition, lupus anticoagulant (LAC) had been detected eight years earlier during his cerebrovascular accident investigations.
1) The most commonly detected subgroups of antiphospholipid antibodies (aPL) are lupus anticoagulant, anticardiolipin antibodies, and anti-[[beta].
The presence of lupus anticoagulant, an antiphospholipid anti, body, increased the risk of stroke by 40-fold and of heart attack by 5-fold in a Dutch study that compared young women who had survived these conditions with a healthy control group.
Reported causes of thrombophilia in HIV-infected subjects include antiphospholipid syndrome [1], increased platelet activation [1], elevated homocysteinemia [2], elevated plasma factor VII activity [2], lupus anticoagulant [3], activated protein C resistance [3], protein C deficiency [3,4], and acquired protein S deficiency [4-10].
001) followed by annexin V, lupus anticoagulant and anti [beta]2 glycoprotein 1 ([beta]2GP1).