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jaundice with evidence of liver cell damage and positive antinuclear antibody or LE cell tests, but without evidence of systemic lupus erythematosus; liver biopsies usually show chronic active hepatitis with infiltration by plasma cells, or postnecrotic cirrhosis; serum is negative for hepatitis B antigen. (More often termed autoimmune hepatitis).
Synonym(s): plasma cell hepatitis
Farlex Partner Medical Dictionary © Farlex 2012
autoimmune hepatitisA multisystem disorder that primarily affects women of all ages, coexists with other liver diseases (e.g., chronic viral hepatitis) and is triggered by viral infections (e.g., HAV) and chemicals (e.g., minocycline).
Linked to circulating autoantibodies, and may be linked to other autoimmune disorders—e.g., thyroiditis, diabetes, ulcerative colitis, Coombs-positive haemolytic anaemia, proliferative glomerulonephritis, Sjögren syndrome.
Increased: IgG; anti-nuclear, anti-smooth muscle, anti-LKM, anti-mitochondrial antibodies; and anti-phospholipid antibodies; elevated
Types of autoimmune hepatitis
• Type 1—Most common form of AIH in North America; 80% are women; may have increased anti-smooth muscle antibodies, anti-nuclear antibodies, anti-actin, and often have a marked increase in immune globulins.
• Type 2—Less common than type 1; affects children ages 2 to 14, 90% female; typically have anti-LKM antibodies.
• Type 3—Similar to type 1; 90% occur in younger (age 30–50) females.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
lupoid hepatitisAutoimmune chronic active hepatitis, autoimmune hepatitis Hepatology An autoimmune hepatitis common in young ♀, who often produce anti-nuclear, anti-smooth muscle and antimitochondrial antibodies, termed 'lupoid' for the presence of an LE cell phenomenon, which occurs in merely 15%; LH is characterized by chronic hepatitis, a low risk of CA and response to corticosteroids. See Systemic lupus erythematosus.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
lu·poid hep·a·ti·tis(lū'poyd hep'ă-tī'tis)
Jaundice with evidence of liver cell damage and positive antinuclear antibody or lupus erythematosus (LE) cell tests, but without evidence of systemic LE.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012