A considerable number of patients admitted to the ICU are diagnosed with type of pathologies where extra vascular lung water
content is increased (fluid accumulation in interstitial space and alveoli), leading to impaired gaseous exchange and respiratory distress.
The possible explanation of this is that positive fluid balance increases extravascular lung water
and prolong mechanical ventilator days and also increases the incidence of ventilator associated pneumonia28.
Studies had proved that TNF-a derived TIP peptide inhalation could reduce the extravascular lung water
index as well as increase the PaO(2)/FiO(2) ratio., The protective role of TNF-derived TIP peptide lies in that through binding to epithelial sodium channel-a, it is able to strengthen the barrier function and maintain permeability of the alveolar-capillary barrier.
Abbreviations LUS - lung ultrasound EVLW - extravascular lung water
BLS - B line score kT/V - marker of dialysis adequacy Dry weight is defined as the lowest tolerated post-dialysis weight and is reached with gradual lowering of weight to the value at which there are minimal signs and symptoms of hypo - or hypervolemia .
"This is an objective marker of lung water
, the accumulation of which can lead to serious complications for already fragile patients.
The right upper lobe was collected for histological assay and the right middle lobe for measurement of lung water
The clinical usefulness of extravascular lung water
and pulmonary vascular permeability index to diagnose and characterize pulmonary edema: a prospective multicenter study on the quantitative differential diagnostic definition for acute lung injury.
To improve the prognosis of patients, the lung tissues should be protected by reducing the lung water
content and inflammation reactions (1).
Mice Analysis Items Batch I (n = 50) Body weight, lung water
content Batch II (n = 50) Body weight, bronchoalveolar lavage fluid (BALF) analysis, histopathology, immunofluorescence Batch III (n = 50) Body weight, oxidative stress markers, western blot Mice in each batch were divided into five groups: (i) normal control group, (ii) model group, (iii) high-dose SP group (200 mg/kg), (iv) medium-dose SP group (400 mg/kg), and (v) low-dose SP group (800 mg/kg) (n = 10 for each group).
As an index of lung edema, the amount of extravascular lung water
After treatment, extravascular lung water
index, intrathoracic blood volume index, systemic vascular resistance index and cardiac index of the two groups were significantly improved compared with those before treatment (Pless than 0.05).
IRI is an acute injury or insult to the lung that manifests with increased vascular permeability, lung water
and alveolar insult.