lung surfactant

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Related to lung surfactant: Pulmonary surfactant, lung surfactant drugs


(sur-fak'tant) [ surf(ace)-act(ive) a(ge)nt]
A surface-active agent that lowers surface tension (e.g., oils and various forms of detergents). Artificial surfactants may be given endotracheally to relieve respiratory distress.

lung surfactant

Pulmonary surfactant.

modified natural surfactant

A replacement phospholipid from a natural source with some components removed.

pulmonary surfactant

A lipoprotein secreted by type II alveolar cells that decreases the surface tension of the fluid lining the alveoli, permitting expansion. Synthetic lung surfactant is available for treating patients with respiratory distress syndrome. In obstetrics, fetal production of surfactant can be stimulated by administration of a glucocorticoid 24 to 48 hr before an inevitable preterm birth.
Synonym: lung surfactant See: betamethasone; lecithin-sphingomyelin ratio
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Effect of humidity on lung surfactant films subjected to dynamic compression/expansion cycles.
Lung surfactant. Biochim Biophys Acta 1974;344:241-61.
Comparison of Infasurf (calf lung surfactant extract) to Survanta (beractant) in the treatment and prevention of RDS.
1 The Artificial Lung Surfactant, Citracal, ET-2000 Guardrail End Treatment and Lycos, Inc.
The company anticipates a $40 million annual market for diagnosis of RDS and treatment with artificial lung surfactant.
According to the company, it will display data from the effect of lung surfactant on the in vitro activity of dalbavancin against Staphylococcus aureus and Streptococcus pneumoniae study and another dalbavancin-related study in San Diego Convention Center Halls F-H from 18 - 20 October 2012.
Other topics include secretion and absorption by colonic crypts, novel renal amino acid transporters, exocytosis of lung surfactant, calcium-activated chloride channels, and the function of chloride channels in the kidney.
In this regard, it is important to keep in mind the role of lung surfactant. Lung surfactant is known to modulate immune functions in the lung (Wright 1997); we mention its role in particular because we have some preliminary data to suggest that lung surfactant may enhance cytokine production in the lung fibroblasts.
(Nasdaq: DSCO), Doylestown, Pa., a biopharmaceutical company developing its proprietary surfactant technology as Surfactant Replacement Therapies for respiratory diseases, has initiated a Phase 1b clinical trial to evaluate the safety and tolerability of its humanized lung surfactant, delivered as an inhaled aerosol, to treat hospitalized patients who suffer from asthma.
RESEARCH TRIANGLE PARK, N.C.--The Food and Drug Administration has approved a new protein-free synthetic lung surfactant that is said to reduce the severity of respiratory distress syndrome, the most common cause of death and disability among premature infants.
Factors that have been postulated to contribute to altered permeability include lung hypoxia, chronicity of pulmonary collapse, rapid re-expansion and subsequent occurrence of strong negative pressure in the thorax, application of excessive intrathoracic suction pressure, rapid increase in blood flow to the involved lung during re-expansion, an increase in the pressure gradient between the alveolar space and the pulmonary capillary, disturbance of lymphatic flow in the 1ung, and destruction of lung surfactant. [4]