The study will evaluate the ability of the drug to decrease the size and growth of lung metastases
in dogs when administered in combination with doxorubicin.
There were also more lung metastases
in the former group.
DV281 is Dynavax's proprietary investigational TLR9 agonist designed specifically for focused delivery to tumor-burdened lungs for the treatment of primary lung tumors and lung metastases
. The Phase 1b clinical study is ongoing.
However, if this was the principal way of the entire metastases, the incidence of accompanying lung metastases
would be higher.
Ninety five out of 121 patients were proved to have metastases histopathologically and 26 patients had highly suspicious metastases by conventional imaging [8 patients with multiple lung metastases
detected by C T, 10 patients with multiple bone metastases detected by scintigraphy and/or magnetic resonance imaging (MRI), 5 patients with multiple liver metastases by MRI and/or US, and 3 patients with brain metastases detected by MRI].
Initial PET/CT demonstrated FDG avid liver and lung metastases
with a small focus of residual activity at the glabella consistent with incomplete resection (Figure 4).
from extrapulmonary primary malignancies are frequent, but EBM is rare.
One of these initially presented with lung metastases
and subsequently developed metastases in the contralateral adrenal gland, kidney, lymph nodes, liver and separate metastases to the duodenum and jejunum.
Patients with a limited number of lung metastases
can hope for a longer disease-free survival if both the primary tumor and the metastases are treated (1).
Extrapulmonary metastases, in contrast to lung metastases
, are less common, so that PAIS is rarely diagnosed with initial symptoms related to an extrapulmonary metastasis.
The lung is most common site of metastatic spread, and the majority of newly diagnosed patients have undetectable microscopic lung metastases
at the time of diagnosis providing the rational for giving preoperative and postoperative chemotherapy.
From the data, it is evident that an unknown proportion of the cases were a result of missed staging, where retrospective examination of undefinable small nodules on pretransplant CT scans of the thorax in 7/17 patients later proved to be lung metastases
that were present before transplant .