The compound in question, ECF843, is a recombinant human lubricin
) protein, which was developed by US-based Lubris LLC.
Transcription, translation, and function of lubricin
, a boundary lubricant, at the ocular surface.
Interestingly, the researchers also found that lubricin
helped extend the life of non-adherent or loosely adherent fibroblasts.
26 ( ANI ): Researchers have found that adding lubricin - a protein that our bodies naturally produce - to the fluid in our joints may reduce the risk of or even prevent osteoarthritis (OA).
The discoveries were made in part by studying the knees of mice, which genetically lack lubricin, causing an aggressive arthritis in spite of high levels of hyaluronic acid in the synovial fluid.
The molecule kartogenin (shown below) revs up genes that code for cartilage proteins, notably aggrecan, type 2 collagen and lubricin
A lack of lubricin
and a change of the synovial fluid into a Newtonian fluid were observed in patients with rheumatoid arthritis, see Sokoloff (58) and Pieterse (59).
Because of that, in the last decade there has been a revived interest in the role of boundary lubricants such as phospholipids, lubricin
, and related glycoproteins like superficial zone proteins and PG.
The researchers found that, rather than simply reducing friction, lubricin
forms a very thin barrier that repels joint surfaces to prevent their contact.
The study by experts from the Baylor College of Medicine in Houston, Texas, reveals that a naturally-occurring protein called lubricin
- or Proteoglycans 4 - protects against osteoarthritis.
25 reportedly improves processing of rigid PVC during calendering and injection molding.
Washington, Oct 24 (ANI): Lubricin
, a synovial fluid glycoprotein, reduces wear to bone cartilage, a team of researchers in North Carolina has discovered.