lowest-observed-adverse-effect level

lowest-observed-adverse-effect level

Toxicology The lowest concentration of a chemical in a study, or group of studies, that produces statistically or biologically significant ↑ in frequency or severity of adverse effects between the exposed population and an appropriate control. See Ames test. Cf No-observed-adverse-effect level.
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An acceptable daily exposure (ADE) value of 1 mg/day was determined for sitagliptin using the lowest clinical dose of 25 mg as a lowest-observed-adverse-effect level (LOAEL) and a composite uncertainty factor of 25 to account for interindividual variability and extrapolation to a no-observed-adverse-effect level (NOAEL).
Environmental Protection Agency, which is based on a lowest-observed-adverse-effect level of 50 milligrams per kilogram per day.