low-grade astrocytoma


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low-grade astrocytoma

A relatively slow-growing brain cancer made up of glial cells that have an atypical cellular appearance when viewed microscopically. They are known under the WHO grading system as grade II astrocytomas. The median survival after diagnosis is 7 to 8 years.
See also: astrocytoma
References in periodicals archive ?
1) Surgery is the cornerstone of treatment for the majority of low-grade astrocytomas, while postoperative radiotherapy has been shown to lengthen the progression-free period without significantly affecting the overall survival - median survival is 7.
Compared with the differential diagnoses suggested when evaluating the conventional MRI, the multimodal MRI (MRS and/or PWI) provided additional information in 27 (61%) patients and helped to differentiate between lymphoma and GBM in 7 patients (4 GBM and 3 lymphomas); between GBM and metastases in 7 patients; between high-grade and low-grade astrocytomas in 5 patients; between various other tumours in 4 patients; and between tumours and non-neoplastic conditions in 4 patients (Table 3).
A review of the Low-Grade Astrocytoma products under development by companies and universities/research institutes based on information derived from company and industry-specific sources.
Coverage of the Low-Grade Astrocytoma pipeline on the basis of route of administration and molecule type.
BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas.
More sensitive and specific markers to distinguish low-grade astrocytoma from reactive gliosis will be welcome diagnostic adjuncts as intraocular biopsy evolves as a clinical resource.
17 Unlike most low-grade astrocytomas of the brain, they do not overexpress p53, nor do they display the K1AA-BRAF fusion mutation seen in pilocytic astrocytoma.
The median survival of patients with low-grade astrocytomas is 5 years, and most patients die from progression of their disease to a high-grade astrocytoma.
Low-grade tumors, including low-grade astrocytomas, oligodendrogliomas and mixed tumors, have been found over time to progress to high grade tumors.
71-74) These genetic abnormalities are rare in diffuse astrocytic gliomas and, therefore, may allow the differentiation of pilocytic astrocytomas from low-grade astrocytomas, especially if combined with IDH mutational analysis.
Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single-nucleotide polymorphism-based genotype arrays results in a novel BRAF fusion gene.

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