It is widely accepted that elevated low-density lipoprotein
(LDL) cholesterol increases the risk of coronary heart disease (CHD).
Involvement of beta 2-glycoprotein I and anticardiolipin antibodies in oxidatively modified low-density lipoprotein
uptake by macrophages.
Watanabe et al., "Small dense low-density lipoproteins
cholesterol can predict incident cardiovascular disease in an urban Japanese cohort: the Suita study," Journal of Atherosclerosis and Thrombosis, vol.
Fluorescence properties of oxidised human plasma low-density lipoproteins
. Biochim Biophys Acta 1995;1254:135-9.
Lowering cholesterol reduces the body's production of cholesterol-carrying molecules known as low-density lipoproteins
. Ramsdell suspects those same molecules are responsible for transporting the fat-soluble brevetoxin from the blood into tissues where the poison can do its worst.
While other studies have shown reductions in total cholesterol with garlic oil supplementation, in this study total cholesterol, high-density lipoproteins, low-density lipoproteins
, and triglyceride levels were virtually unchanged following 12 weeks of either garlic oil or placebo.
, or LDLs, deliver cholesterol to vessel walls, where it can foster artery-clogging plaque.
To explain the finding, the researchers focused on low-density lipoproteins
(LDLs) and monocytes.
That won't be easy, she concedes, because her team's novel technique is "cumbersome and time consuming." It takes 2 days to isolate the blood's low-density lipoproteins
(LDLs), the so-called bad lipoproteins, and 2 days more to quantify their oxidization.
254), the length of time fats circulate in the blood, and the share of cholesterol residing in especially small, low-density lipoproteins
(LDLs), which pose a potent heart-attack risk (SN: 9/21/96, p.
Vinson and his colleagues found that, matched molecule for molecule, chocolates flavonoids are more powerful than vitamins such as ascorbic acid in limiting the oxidation of cholesterol circulating in low-density lipoproteins
(LDLs) and very-low-density lipoproteins.
During the high-protein phase, the participants' blood concentrations of triglycerides and low-density lipoproteins
fell, while high-density-lipoprotein concentrations climbed.