low-density lipoprotein receptors
low-den·si·ty lip·o·pro·tein re·cep·tors
receptors on the surface of cells, especially liver cells, which bind to low-density lipoprotein and promote clearance of low-density lipoprotein from the plasma.
References in periodicals archive
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Low-density lipoprotein receptors play an important role in the inhibition of prostate cancer cell proliferation by statins.
Liu et al., "Expression of lectin-like oxidized low-density lipoprotein receptors during ischemia-reperfusion and its role in determination of apoptosis and left ventricular dysfunction," Journal of the American College of Cardiology, vol.
Lorenz, "The expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1) on human vascular smooth muscle cells and monocytes and its down-regulation by lovastatin," Biochemical Pharmacology, vol.
Kuge et al., "Targeting of lectinlike oxidized low-density lipoprotein receptor 1 (LOX-1) with99mTc-labeled anti-LOX-1 antibody: potential agent for imaging of vulnerable plaque," Journal of Nuclear Medicine, vol.
The isoforms are metabolically distinct, differing in their affinity for lipoprotein particles and the extent to which they bind both apoE and low-density lipoprotein receptors (Fullerton et al., 2000).
In another report to appear in a forthcoming Molecular Endocrinology, Cornish and her colleagues present evidence that lactoferrin affects osteoblasts by binding to cell-surface proteins called low-density lipoprotein receptors.
These include apolipoproteins (chapters 10, 16, and 17), lipoprotein subfractions (chapters 13, 14, 24, and 28), lipoprotein(a) (chapter 15), lipoprotein oxidation (chapter 18), lipases (chapter 19), cholesterol ester transfer protein (chapter 20), lecithin:cholesterol acyl transferase (chapter 21), phospholipids (chapter 22), nonesterified fatty acids (chapter 23), triglyceride-rich lipoprotein remnants (chapter 25), and low-density lipoprotein receptors (chapter 26).
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