LDLR

(redirected from low-density lipoprotein receptor)

LDLR

A gene on chromosome 19p13.2 that encodes a cell surface protein involved in receptor-mediated endocytosis of low-density lipoprotein (LDL), the major cholesterol-carrying lipoprotein of plasma, which it transports into cells by endocytosis. Internalisation of the receptor-ligand complex requires clustering into clathrin-coated pits.
References in periodicals archive ?
Exon 4 of low-density lipoprotein receptor gene were amplified by polymerase chain reaction.
ANGPTL3 may also be involved in regulating apolipoprotein B particle containing synthesis and hepatocyte clearance of LDL-C through mechanisms independent of the low-density lipoprotein receptor (Xu et al., 2018).
The oxidized low-density lipoprotein receptor 1 (OLR1), also known as LOX1, is a type-II membrane cell-surface protein [4], that plays an important role in the degradation of oxidized low-density lipoprotein (Ox-LDL) and adipocyte proliferation [5].
Specifically, the panel recommends that testing include the genes encoding the low-density lipoprotein receptor, apolipoprotein B, and proprotein convertase subtilisin/kexin 9.
Discovered in 1922, the Very Low-Density Lipoprotein Receptor (VLDLR) protein has long been known to facilitate the migration of neurons in the developing brain and to play a role in cholesterol uptake.
Discovered in 1922, the Very Low-Density Lipoprotein Receptor (VLDLR) protein, has long been known to facilitate the migration of neurons in the developing brain and to play a role in cholesterol uptake.
According to the report available with The Nation, the research paper co-authored by acting rector COMSATS has been found similar to another research article named 'A common polymorphism decreases low-density Lipoprotein receptor exon 12 splicing efficiency and associates with increased cholesterol' published in 2007.
Mitsuoka et al., "Variation in the human lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) gene is associated with plasma soluble LOX-1 levels," Experimental Physiology, vol.
Low-density lipoprotein receptor gene mutation analysis and structure-function correlation in an Omani arab family with familial hypercholesterolemia.
Cardiovascular risk in relation to functionality of sequence variants in the gene coding for the low-density lipoprotein receptor: a study among 29,365 individuals tested for 64 specific low-density lipoprotein-receptor sequence variants.
Common low-density lipoprotein receptor mutations in the French Canadian population.

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