low molecular weight heparins

low molecular weight heparins

Heparins that can be isolated from standard heparin by differential precipitation with ethyl alcohol or by gel filtration chromatography or other means. These heparins differ in their mode of action and pharmacological and immunological properties from normal heparin and are useful in cases in which side effects such as heparin-induced THROMBOCYTOPENIA have occurred. They have advantages over heparin in the treatment of venous thrombosis. They bind much less avidly to heparin-binding proteins than does heparin. This increases their bioavailability at low doses and makes their anticoagulant response more predictable. The group includes certoparin (Alphaparin), dalteparin sodium (Fragmin), enoxaparin (Clexane), reviparin sodium (Clivarine) and tinzaparin (Innohep).
References in periodicals archive ?
Contract notice: framework agreement for the supply of subcutaneous syringes of low molecular weight heparins
Implications for the use of unfractionated and low molecular weight heparins as therapeutic agents.
Safety and efficacy of low molecular weight heparins for hemodialysis in patients with end-stage renal failure: A meta-analysis of randomized trials.
Fixed dose subcutaneous low molecular weight heparins versus adjusted dose unfractionated heparin for venous thromboembolism.
M2 PHARMA-September 13, 2010-Momenta wins US patent for evaluating mixtures of low molecular weight heparins by chain mapping(C)2010 M2 COMMUNICATIONS
Are all low molecular weight heparins equivalent in the management of venous thromboembolism?
Low molecular weight heparins have been used to reduce thromboembolic risk in both primary care and the hospital setting for at least twenty years (Clagett et al 1995, Imberti et al 2006, Mohr et al 1993, Wolf 1994).
This test may not be performed by all labs, but may be available at labs with a blood bank or those currently testing anti-Xa levels for other low molecular weight heparins. The plasma anti-Xa level should be drawn prior to the dose administration for the second dialysis treatment and then pretreatment for each subsequent dialysis treatment.
DENVER -- Obstetric anesthesiologists are eyeing with trepidation the growing use of low molecular weight heparins for thromboprophylaxis in pregnancy.
Comparison of efficacy and safety of low molecular weight heparins and unfractionated heparin in initial treatment of deep venous thrombosis: a meta-analysis.
Low molecular weight heparins are small fragments of the unfractionated heparin molecule created by chemical or enzymatic depolymerization.(1) These scaled-down versions of the traditional heparin chain have the specific pentasaccharide sequence that is necessary to bind with antithrombin.

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