The answer to the questions of what is responsible for low T3 syndrome, whether low T3 syndrome constitutes an adaptive, and thus beneficial response, or whether it aggravates a patient's condition, is still a matter of debate.
Gao et al (9) showed reduced albumin levels significantly correlated with low T3 syndrome. In contrast to these findings Disel et al (12) reported that there was no significant difference in weight loss and BMI score between their groups.
have classified the patterns of abnormalities of thyroid hormone levels in ESS into four major types namely low T3 syndrome
, low T3 and low T4 syndrome, high T4 syndrome, other variants.3 Low T3 Syndrome
is defined as a condition in which T3 is decreased but T4 and TSH levels remain normal due to the impaired conversion of the inactive pro-hormone T4 to the biologically active hormone T3 by 5 monodeiodinase in the liver.4 It is the most common abnormality amongst NTIs observed.
Wajner, "N-acetylcysteine prevents low T3 syndrome
and attenuates cardiac dysfunction in a male rat model of myocardial infarction," Endocrinology, vol.
Also we estimated the prevalence of SCH and low T3 syndrome
in the healthy group and T2DM patients without and with DN.
Low T3 syndrome
is common in critically ill patients, and it has been well demonstrated that low T3 syndrome
was independently associated with greater mortality rate and worse functional outcomes across different populations of somatic patients, including patients after acute cardiac events , patients with respiratory failure , and intensive care unit patients , and after surgery for brain tumor .
* To find an association between Low T3 syndrome
and chronic heart failure.
Frequent overt or subclinical thyroid dysfunctions, including persistent low T3 syndrome
, chronic thyroiditis, subclinical hypo- or hyperthyroidism, and neoplastic transformation, have been described after allo-HSCT [7, 26, 88, 89] and more rarely after auto-HSCT [17, 27, 90].
Low T3 syndrome
is present in nearly 20% of patients with AMI, despite primary percutaneous coronary intervention (PCI).
Acute effects of triiodothyronine replacement therapy in patients with chronic heart failure and low T3 syndrome
: a randomized placebo-controlled study.
In recent years, attention has shifted towards milder forms of thyroid disease, such as the so-called "low T3 syndrome
", which is characterized by an isolated reduction in circulating levels of the biologically active form of thyroid hormone, triiodothyronine (T3).
"Low T3 syndrome
" was the common type in our study.