lovastatin


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Related to lovastatin: simvastatin

lovastatin

 [lo´vah-stat″in]
an antihyperlipidemic agent that acts by inhibiting cholesterol synthesis, used in the treatment of hypercholesterolemia and other forms of dyslipidemia and to lower the risks associated with atherosclerosis and coronary heart disease; administered orally.

lovastatin

Altoprev, Apo-Lovastatin (CA), Co Lovastatin (CA), Dom-Lovastatin (CA), Gen-Lovastatin (CA), Mevacor, Novo-Lovastatin (CA), Nu-Lovastatin (CA), PHL-Lovastatin (CA), PMS-Lovastatin (CA), Ran-Lovastatin (CA), Ratio-Lovastatin (CA), Sandoz Lovastatin (CA)

Pharmacologic class: HMG-CoA reductase inhibitor

Therapeutic class: Antihyperlipidemic

Pregnancy risk category X

Action

Inhibits HMG-CoA reductase, an enzyme crucial to cholesterol synthesis. Decreases total cholesterol and low-density lipoprotein (LDL) levels and increases high-density lipoprotein level.

Availability

Tablets: 10 mg, 20 mg, 40 mg

Tablets (extended-release): 10 mg, 20 mg, 40 mg, 60 mg

Indications and dosages

To reduce LDL, total cholesterol, triglyceride, and apolipoprotein B levels

Adults: Initially, 20 mg P.O. daily. May be increased, as needed, at 4-week intervals to a maximum of 80 mg/day as a single dose or in divided doses. Or 20 mg P.O. (extended-release) daily. May be increased, as needed, at 4-week intervals to a maximum daily dosage of 60 mg.

Heterozygous familial hypercholesterolemia in boys and postmenarchal girls ages 10 and older who have high LDL and cholesterol levels despite adequate trial of diet therapy

Adolescents ages 10 to 17: 10 to 40 mg P.O. daily, with adjustments made at 4-week intervals

Dosage adjustment

• Severe renal insufficiency

Off-label uses

• High-risk patients with diabetic dyslipidemia, familial dysbetalipoproteinemia, familial combined hyperlipidemia, or nephrotic hyperlipidemia

Contraindications

• Hypersensitivity to drug, its components, or angiotensin-converting enzyme inhibitors
• Active hepatic disease or unexplained persistent hepatic enzyme elevation
• Concurrent gemfibrozil or azole antifungal therapy
• Pregnancy or breastfeeding

Precautions

Use cautiously in:
• cerebral arteriosclerosis, heart disease, renal impairment, severe acute infection, severe hypotension or hypertension, uncontrolled seizures, myopathy, visual disturbances, major surgery, trauma, alcoholism
• severe metabolic, endocrine, or electrolyte problems
• women of childbearing age
• children.

Administration

• Give daily dose with evening meal.
• Increase dosage at intervals of 4 weeks or longer, as ordered.
• Don't give with grapefruit juice (may increase drug blood level).

Discontinue if alanine aminotransferase (ALT) or aspartate aminotransferase (AST) level exceeds three times the upper limit of normal.

Adverse reactions

CNS: headache, dizziness, asthenia

EENT: blurred vision, eye irritation

GI: nausea, vomiting, constipation, diarrhea, abdominal pain or cramps, dyspepsia, flatulence

Hepatic: hepatotoxicity

Musculoskeletal: myalgia, cramps, rhabdomyolysis

Skin: pruritus, rash, photosensitivity

Other: hypersensitivity reaction

Interactions

Drug-drug.Azole antifungals, cyclosporine, erythromycin, folic acid derivatives, gemfibrozil, niacin: increased risk of myopathy and rhabdomyolysis

Bile acid sequestrants: decreased lovastatin blood level

Isradipine: increased lovastatin clearance

Warfarin: increased prothrombin time, bleeding

Drug-diagnostic tests.ALT, AST: increased levels

Drug-food.Grapefruit juice: increased lovastatin blood level

Drug-herbs.Red yeast rice: increased risk of adverse reactions

Chaparral, comfrey, germander, jin bu huan, kava, pennyroyal, St. John's wort: increased risk of hepatotoxicity

Patient monitoring

• Obtain liver function tests before starting therapy, 6 and 12 weeks after therapy begins or dosage is increased, and periodically thereafter.

Patient teaching

• Tell patient to take immediate-release tablets with evening meal or extended-release tablets at bedtime.
• Instruct patient not to break, crush, or chew extended-release tablets.
• Emphasize importance of cholesterol-lowering diet and other therapies, such as exercise and weight control.

Instruct patient to report unexplained muscle pain, tenderness, or weakness, as well as signs or symptoms of hepatotoxicity (fever, malaise, abdominal pain, yellowing of skin or eyes, clay-colored stools, or tea-colored urine).

Advise patient to contact prescriber immediately if she is breastfeeding or suspects pregnancy.
• Tell patient not to use herbs without consulting prescriber.
• Inform patient that drug may cause photosensitivity. Caution him to avoid excessive sun or heat lamp light.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, foods, and herbs mentioned above.

lovastatin

/lo·va·stat·in/ (lo´vah-stat″in) an antihyperlipidemic agent that acts by inhibiting cholesterol synthesis, used in the treatment of hypercholesterolemia and other forms of dyslipidemia and to lower the risks associated with atherosclerosis and coronary heart disease.

lovastatin

(lō′və-stăt′n)
n.
A statin, C24H36O5, that blocks the body's synthesis of cholesterol and is administered especially to individuals at risk for heart disease.

lovastatin

Mevacor® Cardiology A lipid-lowering agent used to manage hypercholesterolemia and other dyslipidemias including primary mixed and primary moderate hyperlipidemias, diabetic dyslipidemia and hyperlipidemia of nephrotic syndrome in healthy volunteers, ↓ LDL-C by 35%, apoB by 25%, VLDL-C and IDL-C by 30-40%, ↑ HDL-C by 7% Lab ↓ Total cholesterol, ↓ LDL-C, ↓ TGs, ↑ HDL-C. See Statin. Cf Cholesterol-lowering drugs, Gemfibrozil, HMG CoA reductase inhibitors.

lovastatin

(lō´vəstat´ən),
n brand name: Mevacor;
drug class: cholesterol-lowering agent;
action: inhibits HMG-CoA reductase enzyme, which reduces cholesterol synthesis;
uses: adjunct in primary hypercholesterolemia, mixed hyperlipidemia.
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Like lovastatin levels, GABA levels also increase with age in pu-erh tea.
The amounts of lovastatin compounds in products tested by ConsumerLab.
A statistically significant association was found between the rate of dyslipidemia control and the following variables: sex, age, diabetes mellitus, high HDL-C, history of MI and stroke, use of hydrochlorothiazide or ACE inhibitors/ARBs, non-adherence to treatment, and the dose of lovastatin.
Zimmerman and his colleagues also studied lovastatin in an experimental model of bacterial sepsis, a severe whole-body inflammatory state that can also lead to cognitive impairment.
Statins that belong to this group ar Lovastatin, Pravastatin, Simvastatin
LDL-LOWERING OPTIONS Drug Efficacy Side effects class/examples Statins Atorvastatin Most potent at Digestive (Lipitor) lowering LDL problems Fluvastatin cholesterol; can (nausea, (Lescol) reduce stomach pain, Lovastatin triglycerides and diarrhea), (Mevacor) slightly increase muscle pain and Pravastatin HDL ("good") weakness, liver (Levalo) cholesterol; have abnormalities; Pravastatin some anecdotal J (Pravachol) anti-inflammatory reports of Rosuvastatin effects.
All patients were randomized to following groups: the 1st group (n=44) received lovastatin (20-60 mg/day), hypolipidemic diet and physical training; the 2nd group (n=39)--hypolipidemic diet and physical training.
Discuss it with your health care provider and listen to the National Institutes of Health's advice: Since these products may not be standardized and effects are not predictable, there is better evidence in favor of taking prescription drugs such as lovastatin to lower cholesterol.
2 mg of monacolin K plus "a small quantity of lovastatin hydroxyl acid as well as ergosterol and some other components.
Researchers overstimulated brain cells in animals, then treated the cells with the statin drug lovastatin (Altoprev, Mevacor).
Researchers found that cells extracted from the nucleus pulposus (the jelly-like tissue in the center of the spinal discs) and exposed, in vitro, to lovastatin (Altoprev, Mevacor) demonstrated increased synthesis of collagen II, a protein that makes up moveable joints.
In the second study, a post hoc analysis of the Primary Prevention of Acute Coronary Events with Lovastatin in Men and Women with Average Cholesterol Levels: Results of the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS), lovastatin was effective for primary prevention of acute cardiovascular events in patients with chronic kidney disease, but not for reducing loss of kidney function.