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Related to lovastatin: simvastatin


an antihyperlipidemic agent that acts by inhibiting cholesterol synthesis, used in the treatment of hypercholesterolemia and other forms of dyslipidemia and to lower the risks associated with atherosclerosis and coronary heart disease; administered orally.


Altoprev, Apo-Lovastatin (CA), Co Lovastatin (CA), Dom-Lovastatin (CA), Gen-Lovastatin (CA), Mevacor, Novo-Lovastatin (CA), Nu-Lovastatin (CA), PHL-Lovastatin (CA), PMS-Lovastatin (CA), Ran-Lovastatin (CA), Ratio-Lovastatin (CA), Sandoz Lovastatin (CA)

Pharmacologic class: HMG-CoA reductase inhibitor

Therapeutic class: Antihyperlipidemic

Pregnancy risk category X


Inhibits HMG-CoA reductase, an enzyme crucial to cholesterol synthesis. Decreases total cholesterol and low-density lipoprotein (LDL) levels and increases high-density lipoprotein level.


Tablets: 10 mg, 20 mg, 40 mg

Tablets (extended-release): 10 mg, 20 mg, 40 mg, 60 mg

Indications and dosages

To reduce LDL, total cholesterol, triglyceride, and apolipoprotein B levels

Adults: Initially, 20 mg P.O. daily. May be increased, as needed, at 4-week intervals to a maximum of 80 mg/day as a single dose or in divided doses. Or 20 mg P.O. (extended-release) daily. May be increased, as needed, at 4-week intervals to a maximum daily dosage of 60 mg.

Heterozygous familial hypercholesterolemia in boys and postmenarchal girls ages 10 and older who have high LDL and cholesterol levels despite adequate trial of diet therapy

Adolescents ages 10 to 17: 10 to 40 mg P.O. daily, with adjustments made at 4-week intervals

Dosage adjustment

• Severe renal insufficiency

Off-label uses

• High-risk patients with diabetic dyslipidemia, familial dysbetalipoproteinemia, familial combined hyperlipidemia, or nephrotic hyperlipidemia


• Hypersensitivity to drug, its components, or angiotensin-converting enzyme inhibitors
• Active hepatic disease or unexplained persistent hepatic enzyme elevation
• Concurrent gemfibrozil or azole antifungal therapy
• Pregnancy or breastfeeding


Use cautiously in:
• cerebral arteriosclerosis, heart disease, renal impairment, severe acute infection, severe hypotension or hypertension, uncontrolled seizures, myopathy, visual disturbances, major surgery, trauma, alcoholism
• severe metabolic, endocrine, or electrolyte problems
• women of childbearing age
• children.


• Give daily dose with evening meal.
• Increase dosage at intervals of 4 weeks or longer, as ordered.
• Don't give with grapefruit juice (may increase drug blood level).

Discontinue if alanine aminotransferase (ALT) or aspartate aminotransferase (AST) level exceeds three times the upper limit of normal.

Adverse reactions

CNS: headache, dizziness, asthenia

EENT: blurred vision, eye irritation

GI: nausea, vomiting, constipation, diarrhea, abdominal pain or cramps, dyspepsia, flatulence

Hepatic: hepatotoxicity

Musculoskeletal: myalgia, cramps, rhabdomyolysis

Skin: pruritus, rash, photosensitivity

Other: hypersensitivity reaction


Drug-drug.Azole antifungals, cyclosporine, erythromycin, folic acid derivatives, gemfibrozil, niacin: increased risk of myopathy and rhabdomyolysis

Bile acid sequestrants: decreased lovastatin blood level

Isradipine: increased lovastatin clearance

Warfarin: increased prothrombin time, bleeding

Drug-diagnostic tests.ALT, AST: increased levels

Drug-food.Grapefruit juice: increased lovastatin blood level

Drug-herbs.Red yeast rice: increased risk of adverse reactions

Chaparral, comfrey, germander, jin bu huan, kava, pennyroyal, St. John's wort: increased risk of hepatotoxicity

Patient monitoring

• Obtain liver function tests before starting therapy, 6 and 12 weeks after therapy begins or dosage is increased, and periodically thereafter.

Patient teaching

• Tell patient to take immediate-release tablets with evening meal or extended-release tablets at bedtime.
• Instruct patient not to break, crush, or chew extended-release tablets.
• Emphasize importance of cholesterol-lowering diet and other therapies, such as exercise and weight control.

Instruct patient to report unexplained muscle pain, tenderness, or weakness, as well as signs or symptoms of hepatotoxicity (fever, malaise, abdominal pain, yellowing of skin or eyes, clay-colored stools, or tea-colored urine).

Advise patient to contact prescriber immediately if she is breastfeeding or suspects pregnancy.
• Tell patient not to use herbs without consulting prescriber.
• Inform patient that drug may cause photosensitivity. Caution him to avoid excessive sun or heat lamp light.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, foods, and herbs mentioned above.


/lo·va·stat·in/ (lo´vah-stat″in) an antihyperlipidemic agent that acts by inhibiting cholesterol synthesis, used in the treatment of hypercholesterolemia and other forms of dyslipidemia and to lower the risks associated with atherosclerosis and coronary heart disease.


A statin, C24H36O5, that blocks the body's synthesis of cholesterol and is administered especially to individuals at risk for heart disease.


Mevacor® Cardiology A lipid-lowering agent used to manage hypercholesterolemia and other dyslipidemias including primary mixed and primary moderate hyperlipidemias, diabetic dyslipidemia and hyperlipidemia of nephrotic syndrome in healthy volunteers, ↓ LDL-C by 35%, apoB by 25%, VLDL-C and IDL-C by 30-40%, ↑ HDL-C by 7% Lab ↓ Total cholesterol, ↓ LDL-C, ↓ TGs, ↑ HDL-C. See Statin. Cf Cholesterol-lowering drugs, Gemfibrozil, HMG CoA reductase inhibitors.


n brand name: Mevacor;
drug class: cholesterol-lowering agent;
action: inhibits HMG-CoA reductase enzyme, which reduces cholesterol synthesis;
uses: adjunct in primary hypercholesterolemia, mixed hyperlipidemia.
References in periodicals archive ?
Lovastatin or monacolin K inhibits the enzyme hydroxyl methylglutary I coenzyme A (HMG CoA) reductase that catalyzes the reduction of HMG-CoA to mevalonate during the initial synthesis of cholesterol.
Pimentel concluded that, of the various statins examined, lovastatin lactone was the only effective inhibitor of methane production in the stool homogenates, significantly inhibiting methane levels by -65% compared to the control stool.
The amounts of lovastatin compounds in products tested by ConsumerLab.
Zimmerman and his colleagues also studied lovastatin in an experimental model of bacterial sepsis, a severe whole-body inflammatory state that can also lead to cognitive impairment.
In patients with a high risk of hepatic insufficiency, the addition of ezetimibe to the lowest dose of lovastatin may be helpful in preventing adverse effects of high-dose lovastatin while gaining the full benefits of high-dose lovastatin.
One group ate meals low in saturated fats, while another had the same low fat diet plus a daily 20mg dose of lovastatin.
6), (7) The main active ingredients in Chinese red rice are hydroxymethylglutaryl coenzyme reductase inhibitors, primarily lovastatin (also referred to as monacolin K or mevinolin).
Patients who stuck with a highly structured diet rich in plant sterols, soy protein, viscous fibers, and almonds maintained their serum LDL-cholesterol level at 30% below their baseline level for a year, a decrease that was similar to the average 33% drop seen in patients treated with 20 mg of lovastatin daily, David J.
Neither lovastatin nor atorvastatin provided similar benefits.
Researchers at Kaiser Permanente followed 68,560 people with diabetes or heart disease who each day took the drug combination, consisting of 40 milligrams of the cholesterol fighter lovastatin and 20 milligrams of the blood pressure pill lisinopril for two years.
The HMG-CoA reductase inhibitor lovastatin impairs IR-stimulated E-selectin expression as analyzed at the level of the protein, mRNA and promoter.