loss of heterozygosity


Also found in: Acronyms, Encyclopedia, Wikipedia.

loss of heterozygosity

adjective Referring to a mutation that results in the loss of allelic uniqueness, often defined as a ≥ 40% increase in signal intensity of allelic signal.
References in periodicals archive ?
Loss of heterozygosity on chromosome 13 and its association with delayed growth of retinoblastoma.
NF1-associated GISTs almost uniformly do not exhibit gain-of-function activation of KIT or PDGFA (pathogenesis is suggested to be from the loss of heterozygosity of the NF1 gene) and are not likely to respond to imatinib.
The study was carried out to understand the prognostic relevance of loss of heterozygosity (LOH) for chromosome 11 p13, 11p15 and 16q in 135 cases of Wilm's tumour.
Microsatellite instability and loss of heterozygosity in human pterygia.
Karyotypes and analysis of Loss of Heterozygosity (LOH) are routine procedures to detect DNA deletion and serve as TSG location indicators.
Loss of heterozygosity in malignant gliomas involves at least three distint regions on chromosome 10.
This work details DNA microarray applications for the detection and characterization of genomic DNA-associated copy number alteration, loss of heterozygosity, cytosine methylation, protein binding sites, regulatory elements, and replication timing, with emphasis on higher eukaryote (animal) and cancer genomics.
No loss of heterozygosity was observed between wild and broodstock samples or between broodstock and F1 samples.
Loss of heterozygosity is a type of mutation that happens when one chromosome is lost, leaving you with only one working chromosome.
Chromosome loss with concomitant duplication and recombination both contribute most to loss of heterozygosity in vitro.
Small, isolated populations experience genetic drift and the loss of heterozygosity over time (14).