loss of heterozygosity


Also found in: Acronyms, Encyclopedia, Wikipedia.

loss of heterozygosity

adjective Referring to a mutation that results in the loss of allelic uniqueness, often defined as a ≥ 40% increase in signal intensity of allelic signal.
References in periodicals archive ?
Loss of heterozygosity at chromosomes 8p, 9p, and 14q is associated with stage and grade of non-papillary renal cell carcinomas.
Loss of heterozygosity on chromosome 13 and its association with delayed growth of retinoblastoma.
Loss of heterozygosity and p53 expression in Pterygium.
Unbalanced translocation, a major chromosome alteration causing loss of heterozygosity in human lung cancer.
Acquisition of the glioblastoma phenotype during astrocytoma progression is associated with loss of heterozygosity on 10q25-qter.
Loss of heterozygosity is a type of mutation that happens when one chromosome is lost, leaving you with only one working chromosome.
Comparison of allelic ratios from paired blood and paraffin embedded normal tissue for use in a polymerase chain reaction to assess loss of heterozygosity.
Small, isolated populations experience genetic drift and the loss of heterozygosity over time (14).
The investigators focused on DNA aneuploidy and tetraploidy and on alterations in the genes for the tumor-suppressor proteins TP53 and CDKN2A accompanied by a loss of heterozygosity (LOH) for those genes.
17 suggests an intermediate loss of heterozygosity within each colony, but not existence of differentiated bud nests.
Currently available methods for isolating undegraded circulating DNA are limited, and there is a need to develop novel methods which improve the yield of undegraded DNA and to adapt detection assays so that this DNA can be used to detect mutations, microsatellite instabilities, loss of heterozygosity, epigenetic changes, and other molecular genetic changes.
According to previously published research, loss of heterozygosity (LOH) of certain alleles is a positive predictor for chemotherapeutic response and longer survival rates.