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Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
An angiotensin II receptor blocker drug, C22H23ClN6O, used in the form of its potassium salt to treat hypertension.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
losartanCozaar® Pharmacology A sartan which blocks angiotensin II–A-II from binding to AT1, ↓ proteinuria and filtration fraction, inhibits secretion of aldosterone by the adrenal cortex, and ↑ uric acid excretion; in Pts with CHF, losartan ↓ afterload, ↑ cardiac output–effects shared by ACE inhibitors—and prevent left ventricular hypertrophy Side effects Vertigo. See Angiotensin II receptor antagonist, ELITE.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
losartanAn angiotensin II antagonist drug used to treat high blood pressure (HYPERTENSION). In the LIFE trial of this drug, reported on in 2003, a subgroup of diabetic patients taking the drug showed a 37 percent reduction in mortality from heart attacks or strokes and a 39 percent reduction in overall mortality over people on other treatment. The drug appears to be effective in preventing sudden death from heart arrhythmias. A brand name is Cozaar. The drug is available combined with the diuretic drug HYDROCHLOROTHIAZIDE under the brand name Cozaar-Comp.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005