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a benzodiazepine derivative used as an antianxiety agent, sedative-hypnotic, preanesthetic medication, and anticonvulsant, and as an antiemetic in cancer chemotherapy; administered orally, intravenously, or intramuscularly.


Apo-Lorazepam (CA), Ativan, Dom-Lorazepam (CA), Novo-Lorazem (CA), Nu-Loraz (CA), PHL-Lorazepam (CA), PMS-Lorazepam (CA), Pro-Lorazepam (CA)

Pharmacologic class: Benzodiazepine

Therapeutic class: Anxiolytic

Controlled substance schedule IV

Pregnancy risk category D


Unknown. Thought to depress CNS at limbic system and disrupt neurotransmission in reticular activating system.


Injection: 2 mg/ml, 4 mg/ml

Solution (concentrated): 2 mg/ml

Tablets: 0.5 mg, 1 mg, 2 mg

Indications and dosages


Adults: 2 to 3 mg P.O. daily in two or three divided doses. Maximum dosage is 10 mg daily.


Adults: 2 to 4 mg P.O. at bedtime

Premedication before surgery (as antianxiety agent, sedative-hypnotic, or amnestic)

Adults: 0.05 mg/kg (not to exceed 4 mg) deep I.M. injection at least 2 hours before surgery, or 0.044 mg/kg (not to exceed 2 mg) I.V. 15 to 20 minutes before surgery. For greater amnestic effect, give up to 0.05 mg/kg (not to exceed 4 mg) I.V. 15 to 20 minutes before surgery.

Status epilepticus

Adults: 4 mg I.V. given slowly (no faster than 2 mg/minute). If seizures continue or recur after 10 to 15 minutes, repeat dose. If seizure control isn't established after second dose, other measures should be used. Don't exceed 8 mg in 12 hours.

Dosage adjustment

• Elderly or debilitated patients

Off-label uses

• Acute alcohol withdrawal syndrome


• Hypersensitivity to drug, other benzodiazepines, polyethylene or propylene glycol, or benzyl alcohol
• Acute angle-closure glaucoma
• Coma or CNS depression
• Hepatic or renal failure


Use cautiously in:
• hepatic or renal impairment
• history of suicide attempt, drug abuse, depressive disorder, or psychosis
• elderly patients
• pregnant or breastfeeding patients.


• For I.V. use, dilute with equal volume of compatible diluent, such as normal saline solution or dextrose 5% in water. Keep resuscitation equipment and oxygen at hand.

Give each 2 mg of I.V. dose slowly, over 2 to 5 minutes. Don't exceed rate of 2 mg/minute.
• Don't give parenteral form to children younger than age 18.

Adverse reactions

CNS: amnesia, agitation, ataxia, depression, disorientation, dizziness, drowsiness, headache, incoordination, asthenia

CV (with too rapid I.V. administration): hypotension, bradycardia, tachycardia, apnea, cardiac arrest, cardiovascular collapse

EENT: blurred vision, diplopia, nystagmus

GI: nausea, abdominal discomfort

Other: increased or decreased appetite


Drug-drug.CNS depressants (including antidepressants, antihistamines, benzodiazepines, sedative-hypnotics): additive CNS depression

Hormonal contraceptives: increased lorazepam clearance

Drug-herbs.Chamomile, hops, kava, skullcap, valerian: increased CNS depression

Drug-behaviors.Alcohol use: increased CNS depression

Smoking: increased metabolism and decreased efficacy of lorazepam

Patient monitoring

During I.V. administration, monitor ECG and cardiovascular and respiratory status.
• Monitor vital signs closely.
• Evaluate for amnesia.
• Watch closely for CNS depression. Institute safety precautions as needed to prevent injury.

Monitor for signs and symptoms of overdose (such as confusion, hypotension, coma, and labored breathing).
• Assess liver function tests and CBC.

Patient teaching

• Tell patient and family about drug's possible CNS effects. Recommend appropriate safety precautions.
• Explain that with long-term use, drug must be discontinued slowly (typically over 8 to 12 weeks).
• Instruct patient to avoid alcohol, because it increases drowsiness and other CNS effects.
• Caution patient to avoid smoking, because it speeds drug breakdown in body.
• Advise female patient to inform prescriber if she is pregnant or breastfeeding.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, herbs, and behaviors mentioned above.


/lor·a·ze·pam/ (lor-az´ĕ-pam) a benzodiazepine used as an antianxiety agent, sedative-hypnotic, preanesthetic medication, and anticonvulsant.


A benzodiazepine drug, C15H10Cl2N2O2, that acts as a sedative and antianxiety agent and is used therapeutically to control seizures.


a benzodiazepine tranquilizer.
indications It is prescribed in the treatment of anxiety, nervous tension, and insomnia and is given intravenously to abort status epilepticus and for preanesthesia.
contraindications Acute glaucoma, psychosis, pregnancy, or known hypersensitivity to this drug or to any benzodiazepine prohibits its use.
adverse effects Among the more serious adverse effects are drowsiness and fatigue. Withdrawal symptoms may occur on discontinuation of the drug, especially after prolonged use or high dosage.


Neuropharmacology A benzodiazepine anxiolytic, antidepressant, sedative, hypnotic


A benzodiazepine tranquillizer drug similar to diazepam). A brand name is Ativan.


n.pr brand name: Ativan, Lorazepam Intensol;
drug class: benzodiazepine antianxiety (Controlled Substance Schedule IV);
action: depresses subcortical levels of the central nervous system, including limbic system and reticular formation;
uses: anxiety, preoperative sedation, acute alcohol withdrawal symptoms, muscle spasm.


a benzodiazepine derivative used as an antianxiety agent.
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Experts believed Philip had tested the Lorazepam on her then.
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In conclusion, our results demonstrate that silexan is as effective as lorazepam in adults with GAD.
There is a very effective protocol that can be used to withdraw patients from narcotics, using clonidine for the physical withdrawal symptoms and lorazepam for the anxiety, while switching them to an antidepressant for pain control.
Wilde was found to have failed to accurately account for giving two patients the sedative Diazepam and failing to record the reasons for administering Lorazepam, also a sedative, to another.
2004), our case indicates possible exacerbation of withdrawal delirium and psychosis by continued use of lorazepam after delirium had already cleared.
Now specialist nurses willbe allowed to prescribe six controlled drugs: diazepam, lorazepam, midazolam, codeine phosphate, dihydrocodeine tartrate and co-phenotrope.