loratadine


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loratadine

 [lah-rat´ah-dēn]
a nonsedating antihistamine (H1 receptor antagonist) used for treatment of allergic rhinitis and chronic idiopathic urticaria and as a treatment adjunct in asthma; administered orally.

loratadine

Aerius (CA), Alavert, Allertin, Claritin, Claritin RediTabs, Clarityn (UK)

Pharmacologic class: Histamine1-receptor antagonist (second-generation)

Therapeutic class: Antihistamine (nonsedating)

Pregnancy risk category B

Action

Selective histamine1-receptor antagonist. Blocks peripheral effects of histamine release during allergic reactions, decreasing or preventing allergy symptoms.

Availability

Syrup: 1 mg/ml

Tablets: 10 mg

Tablets (rapidly disintegrating): 10 mg

Indications and dosages

Seasonal allergies; chronic idiopathic urticaria

Adults and children ages 6 and older: 10 mg P.O. daily

Children ages 2 to 5: 5 mg P.O. daily

Dosage adjustment

• Renal or hepatic impairment

Contraindications

• Hypersensitivity to drug

Precautions

Use cautiously in:

• renal or hepatic impairment

• elderly patients

• pregnant patients

• children younger than age 2 (safety not established).

Administration

• Give once a day on empty stomach.

• Place rapidly disintegrating tablet on tongue; give with or without water.

• Use rapidly disintegrating tablets within 6 months of opening foil pouch and immediately after opening individual tablet blister.

Adverse reactions

CNS: headache, nervousness, insomnia

EENT: conjunctivitis, earache, epistaxis, pharyngitis

GI: abdominal pain; dry mouth; diarrhea, stomatitis (in children)

Skin: rash, photosensitivity, angioedema

Other: tooth disorder (in children), fever, flulike symptoms, viral infections

Interactions

Drug-food. Any food: increased drug absorption

Patient monitoring

• Watch for adverse reactions, especially in children.

• Assess patient's response to drug.

• Watch for new symptoms or exacerbation of existing symptoms.

Patient teaching

• Advise patient to take exactly as prescribed, once a day on empty stomach.

• Tell patient to report persistent or worsening symptoms.

• Instruct patient to report adverse reactions, such as headache or nervousness.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the foods mentioned above.

loratadine

(lôr-ăt′ə-dēn′)
n.
A nonsedating antihistamine, C22H23ClN2O2, used to treat allergic rhinitis and other allergic disorders.

loratadine

An ANTIHISTAMINE drug used to treat hay fever and other allergic disorders.

antihistamine 

Any substance that reduces the effect of histamine or blocks histamine receptors, usually the histamine 1 (H1) receptor. It is used in the treatment of allergic conjunctivitis and also in the temporary relief of minor allergic symptoms of the eye. Common agents include antazoline sulfate, azelastine hydrochloride, cetirizine, chlorphenamine, emedastine, epinastine hydrochloride, ketotifen, levocabastine, loratadine and olopatadine. See hypersensitivity; mast cell stabilizers.
References in periodicals archive ?
Aliquots of stock solutions were transferred to 10 mL volumetric flasks separately to prepare seven standard solutions in concentration ranges 20-140, 32-128, 18-126, 22-154 and 35-107 ug mL-1 for promethazine, diphenhydramine, desloratadine, levocetirizine and loratadine respectively.
This apart, Morepen also supplies the APIs for Canada and the European Union since 1999, and intermediates for Loratadine for the Japanese market.
Boots sell products, ranging " from Benadryl, One a Day Relief (Cetirizine) at PS6.99 for 14 tablets to Value One-a-Day Allergy Relief (Loratadine) at 99p for seven tablets.
Patients treated with loratadine took 10 mg of loratadine (Lisino, Essex Pharma GmbH) in the morning of each day over the treatment period of 21 days.
Three other studies indicated that intranasal steroids (triamcinolone, fluticasone) relieved eye symptoms more effectively than oral antihistamines (loratadine, fexofenadine) based on mean reductions in TNSS, Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ), and Total Ocular Symptom Score (TOSS).
Because of loratadine's and cetirizine's once-daily dosing, I recommend giving them to your child at bedtime so he or she can sleep through any sedating effects the drugs may have.
* Comment: No new safety or efficacy trials were required for this new formulation of loratadine. Required bioequivalency testing was conducted, according to a company spokesperson.
Four of these agents are currently available for use in children in the U.S.: fexofenadine is indicated for use in children aged 6 years and older, loratadine for children 2 years or older, cetirizine for children 6 months and older, and azelastine for children 5 years and older.
NONSEDATING [H.sub.1]-RECEPTOR ANTAGONISTS Drug Cost/Day * Dosage cetirizine no generic available 10-20 [Zyrtec] [$2.11 (10 mg)] mg/day desloratadine no generic available 5 mg/day [Clarinex] [$2.46] fexofenadine no generic available 180-240 [Allegral [$2.44 (180 mg)] mg/day loratadine $0.20 (10 mg) 10-20 [Claritin] mg/day Drug What the Experts Say ** cetirizine Available in trade formulation only.
Exposure was defined as any maternal use of loratadine from 1 month before pregnancy through the first trimester.
Loratadine, an antihistamine which blocks [H.sub.1] receptors, is a new drug used to treat common allergic symptoms, and is reported to produce effective control of allergic asthmatic symptoms such as shortness of breath.
The most widely prescribed allergy relief product--and, with $3 billion in sales, among the biggest pharmaceutical sellers--Schering-Plough corp.'s Claritin (chemical name loratadine) faces no apparent regulatory or consumer-safety hurdles.